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Effect of perfluoro...
Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo
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- Geng, Dawei, 1986- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Musse, Ayan Au (author)
- School of Science and Technology, Örebro University, Örebro, Sweden,MTM Research Centre
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- Wigh, Viktoria (author)
- School of Science and Technology, Örebro University, Örebro, Sweden,MTM Research Centre
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- Carlsson, Cecilia (author)
- School of Science and Technology, Örebro University, Örebro, Sweden,MTM Research Centre
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- Engwall, Magnus, 1965- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Scherbak, Nikolai, 1967- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
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In: Ecotoxicology and Environmental Safety. - : Elsevier. - 0147-6513 .- 1090-2414. ; 170, s. 691-698
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Perfluorooctanesulfonate (PFOS) is a well-known contaminant in the environment and it has shown to disrupt multiple biological pathways, particularly those related with lipid metabolism. In this study, we have studied the impact of in ovo exposure to PFOS on lipid metabolism in livers in developing chicken embryos using lipidomics for detailed characterization of the liver lipidome. We used an avian model (Gallus gallus domesticus) for in ovo treatment at two levels of PFOS. The lipid profile of the liver of the embryo was investigated by ultra-high performance liquid chromatography combined with quadrupole-time-of-flight mass spectrometry and by gas chromatography mass spectrometry. Over 170 lipids were identified, covering phospholipids, ceramides, di- and triacylglycerols, cholesterol esters and fatty acid composition of the lipids. The PFOS exposure caused dose dependent changes in the lipid levels, which included upregulation of specific phospholipids associated with the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, triacylglycerols with low carbon number and double bond count as well as of lipotoxic ceramides and diacylglycerols. Our data suggest that at lower levels of exposure, mitochondrial fatty acid β-oxidation is suppressed while the peroxisomal fatty acid β -oxidation is increased. At higher doses, however, both β -oxidation pathways are upregulated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Avian model
- Lipidomics
- Liver metabolism
- Mass spectrometry
- Perfluorooctanesulfonate
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Geng, Dawei, 198 ...
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Musse, Ayan Au
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Wigh, Viktoria
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Carlsson, Cecili ...
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Engwall, Magnus, ...
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Oresic, Matej, 1 ...
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show more...
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Scherbak, Nikola ...
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Hyötyläinen, Tuu ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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Ecotoxicology an ...
- By the university
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Örebro University