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Inflammatory Bowel ...
Inflammatory Bowel Disease and Parkinson's Disease : A Nationwide Swedish Cohort Study
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- Weimers, Petra (author)
- Department of Gastroenterology, North Zealand University Hospital, Frederikssund, Denmark
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
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- Sachs, Michael C. (author)
- Karolinska Institutet
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- Saunders-Pullman, Rachel (author)
- Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet
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- Peter, Inga (author)
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
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- Burisch, Johan (author)
- Department of Gastroenterology, North Zealand University Hospital, Frederikssund, Denmark
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- Olén, Ola (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2018-05-16
- 2019
- English.
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In: Inflammatory Bowel Diseases. - : Oxford University Press. - 1078-0998 .- 1536-4844. ; 25:1, s. 111-123
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Background: Few studies have examined the association between inflammatory bowel disease (IBD) and Parkinson's disease (PD).Methods: To estimate the incidence and relative risk of PD development in a cohort of adult IBD, we included all incident IBD patients (n = 39,652) in the Swedish National Patient Register (NPR) between 2002 and 2014 (ulcerative colitis [UC]: n = 24,422; Crohn's disease [CD]: n = 11,418; IBD-unclassified [IBD-U]: n = 3812). Each IBD patient was matched for sex, age, year, and place of residence with up to 10 reference individuals (n = 396,520). In a cohort design, all incident PD occurring after the index date was included from the NPR. In a case-control design, all incident PD occurring before the index date was included. The association between IBD and PD and vice versa was investigated by multivariable Cox and logistic regression.Results: In IBD, there were 103 cases of incident PD, resulting in hazard ratios (HRs) for PD of 1.3 (95% confidence interval [CI], 1.0-1.7; P = 0.04) in UC, 1.1 (95% CI, 0.7-1.7) in CD, and 1.7 (95% CI, 0.8-3.0) in IBD-U. However, these effects disappeared when adjusting for number of medical visits during follow-up to minimize potential surveillance bias. In a case-control analysis, IBD patients were more likely to have prevalent PD at the time of IBD diagnosis than matched controls, with odds ratios of 1.4 (95% CI, 1.2-1.8) in all IBD patients, 1.4 (95% CI, 1.1-1.9) for UC, and 1.6 (95% CI, 1.1-2.3) for CD patients alone.Conclusions: IBD is associated with an increased risk of PD, but some of this association might be explained by surveillance bias. 10.1093/ibd/izy190_video1izy190.video15785623138001.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- inflammatory bowel disease
- Parkinson's disease
- population-based cohort
Publication and Content Type
- ref (subject category)
- art (subject category)
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