Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

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Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls

Pettersson, E. (author): Karolinska Institutet

Lichtenstein, P. (author): Karolinska Institutet

Larsson, Henrik, 1975- (author): Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Song, J. (author): Karolinska Institutet

Agrawal, A. (author): Department of Psychiatry, Washington University in Saint Louis School of Medicine, Saint Louis, MO, USA

Børglum, A. D. (author): Department of Biomedicine, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

Bulik, C. M. (author): Karolinska Institutet

Daly, M. J. (author): Analytic and Translational Genetics Unit (ATGU), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

Davis, L. K. (author): Department of Medicine, Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA

Demontis, D. (author): Department of Biomedicine, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark

Edenberg, H. J. (author): Indiana University School of Medicine, Biochemistry and Molecular Biology, Indianapolis, IN, USA; Indiana University School of Medicine, Medical and Molecular Genetics, Indianapolis, IN, USA

Grove, J. (author): Department of Biomedicine, Aarhus University, Aarhus, Denmark; iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark; BiRC-Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark

Gelernter, J. (author): Yale University School of Medicine, Genetics and Neurobiology, New Haven, CT, USA; US Department of Veterans Affairs, Psychiatry, West Haven, CT, USA; Yale University School of Medicine, Psychiatry, New Haven, CT, USA

Neale, B. M. (author): Analytic and Translational Genetics Unit (ATGU), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

Pardiñas, A. F. (author): Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales

Stahl, E. (author)

Walters, J. T. R. (author): Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, Wales, UK

Walters, R. (author): Analytic and Translational Genetics Unit (ATGU), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

Sullivan, P F (author): Karolinska Institutet

Posthuma, D. (author): Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands; Department of Clinical Genetics, VU University Medical Center (VUMC), Amsterdam, The Netherlands

Polderman, T. J. C. (author): Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research (CNCR), Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands

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Cambridge University Press, 2019
2019
English.
In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 49:7, s. 1166-1173

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Most studies underline the contribution of heritable factors for psychiatric disorders. However, heritability estimates depend on the population under study, diagnostic instruments, and study designs that each has its inherent assumptions, strengths, and biases. We aim to test the homogeneity in heritability estimates between two powerful, and state of the art study designs for eight psychiatric disorders.METHODS: We assessed heritability based on data of Swedish siblings (N = 4 408 646 full and maternal half-siblings), and based on summary data of eight samples with measured genotypes (N = 125 533 cases and 208 215 controls). All data were based on standard diagnostic criteria. Eight psychiatric disorders were studied: (1) alcohol dependence (AD), (2) anorexia nervosa, (3) attention deficit/hyperactivity disorder (ADHD), (4) autism spectrum disorder, (5) bipolar disorder, (6) major depressive disorder, (7) obsessive-compulsive disorder (OCD), and (8) schizophrenia.RESULTS: Heritability estimates from sibling data varied from 0.30 for Major Depression to 0.80 for ADHD. The estimates based on the measured genotypes were lower, ranging from 0.10 for AD to 0.28 for OCD, but were significant, and correlated positively (0.19) with national sibling-based estimates. When removing OCD from the data the correlation increased to 0.50.CONCLUSIONS: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods. The findings also highlight large differences in genetic and environmental influences between psychiatric disorders, providing future directions for etiological psychiatric research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)

Keyword

ADHD
alcohol dependence
anorexia nervosa
autism spectrum disorders
bipolar disorder
genes
heritability
major depressive disorder
obsessive compulsive disorder
schizophrenia

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

Articles in the publication: Psychological Me ...

By the university: Örebro University; Karolinska Institutet

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