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Body mass index in ...
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Hagström, HannesKarolinska Institutet
(author)
Body mass index in early pregnancy and future risk of severe liver disease : a population-based cohort study
- Article/chapterEnglish2019
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2019-02-03
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Blackwell Science Ltd.2019
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Numbers
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LIBRIS-ID:oai:DiVA.org:oru-72885
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-72885URI
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https://doi.org/10.1111/apt.15162DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-167638URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140422786URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Stockholm County (Clinical Postdoctorial Appointment) Bengt Ihre Fellowship
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BACKGROUND: In young men, high body mass index (BMI) has been linked to liver disease later in life, but it is unclear if this also applies to women.AIM: To study the association between BMI early in life and development of liver disease later in life in women.METHODS: We obtained data on early pregnancy BMI from 1 139 458 Swedish women between 1992 and 2015. National registers were used to ascertain incident severe liver disease, defined as cirrhosis, decompensated liver disease (hepatocellular carcinoma, oesophageal varices, hepatorenal syndrome or hepatic encephalopathy) or liver failure. A Cox regression model was used to investigate associations of BMI with incident severe liver disease adjusting for maternal age, calendar year, country of birth, smoking, civil status and education.RESULTS: (95% CI 1.02-1.05). A diagnosis of diabetes was associated with an increased risk of severe liver disease independent of baseline BMI.CONCLUSION: A high BMI early in life in women is associated with a dose-dependent, increased risk for future severe liver disease.
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Höijer, JonasUnit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
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Andreasson, AnnaKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet(Swepub:su)anan6088
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Bottai, MatteoKarolinska Institutet
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Johansson, KariKarolinska Institutet
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Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Orebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York, USA(Swepub:oru)jsln
(author)
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Stephansson, OlofKarolinska Institutet
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Karolinska InstitutetUnit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
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In:Alimentary Pharmacology and Therapeutics: Blackwell Science Ltd.49:6, s. 789-7960269-28131365-2036
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