Body mass index in early pregnancy and future risk of severe liver disease: a population-based cohort study

Body mass index in early pregnancy and future risk of severe liver disease : a population-based cohort study

Funding Agencies:Stockholm County (Clinical Postdoctorial Appointment) Bengt Ihre Fellowship
BACKGROUND: In young men, high body mass index (BMI) has been linked to liver disease later in life, but it is unclear if this also applies to women.AIM: To study the association between BMI early in life and development of liver disease later in life in women.METHODS: We obtained data on early pregnancy BMI from 1 139 458 Swedish women between 1992 and 2015. National registers were used to ascertain incident severe liver disease, defined as cirrhosis, decompensated liver disease (hepatocellular carcinoma, oesophageal varices, hepatorenal syndrome or hepatic encephalopathy) or liver failure. A Cox regression model was used to investigate associations of BMI with incident severe liver disease adjusting for maternal age, calendar year, country of birth, smoking, civil status and education.RESULTS: (95% CI 1.02-1.05). A diagnosis of diabetes was associated with an increased risk of severe liver disease independent of baseline BMI.CONCLUSION: A high BMI early in life in women is associated with a dose-dependent, increased risk for future severe liver disease.

Höijer, JonasUnit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden (author)
Andreasson, AnnaKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet(Swepub:su)anan6088 (author)
Bottai, MatteoKarolinska Institutet (author)
Johansson, KariKarolinska Institutet (author)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Orebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York City, New York, USA(Swepub:oru)jsln (author)
Stephansson, OlofKarolinska Institutet (author)
Karolinska InstitutetUnit of Biostatistics, Institute of Environmental Medicine, Solna, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

In:Alimentary Pharmacology and Therapeutics: Blackwell Science Ltd.49:6, s. 789-7960269-28131365-2036

By the author/editor: Hagström, Hannes; Höijer, Jonas; Andreasson, Anna; Bottai, Matteo; Johansson, Kari; Ludvigsson, Jona ...; show more...; Stephansson, Olo ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

By the university: Örebro University; Stockholm University; Karolinska Institutet

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