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Emergence and Sprea...
Emergence and Spread of Cephalosporin-Resistant Neisseria gonorrhoeae with Mosaic penA Alleles, South Korea, 2012-2017
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- Lee, Hyukmin (author)
- Yonsei University College of Medicine, Seoul, South Korea
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- Suh, Young Hee (author)
- Yonsei University College of Medicine, Seoul, South Korea
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- Lee, Sunhwa (author)
- Seegene Medical Foundation, Seoul, South Korea
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- Kim, Yong-Kyun (author)
- Samkwang Medical Laboratories, Seoul, South Korea
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- Han, Mi-Soon (author)
- U2 Clinical Laboratories, Seoul, South Korea
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- Bae, Hye Gyung (author)
- Green Cross Laboratories, Yongin, South Korea
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,World Health Organization Collaborating Centre for Gonorrhoea and other STIs, Örebro University, Örebro, Sweden
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- Lee, Kyungwon (author)
- Yonsei University College of Medicine, Seoul, South Korea
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(creator_code:org_t)
- Centers for Disease Control and Prevention, 2019
- 2019
- English.
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In: Emerging Infectious Diseases. - : Centers for Disease Control and Prevention. - 1080-6040 .- 1080-6059. ; 25:3, s. 416-424
- Related links:
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https://doi.org/10.3...
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https://wwwnc.cdc.go...
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https://urn.kb.se/re...
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Abstract
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- In South Korea, surveillance of antimicrobial drug resistance in Neisseria gonorrhoeae is extremely limited. We describe the emergence and subsequent national spread of N. gonorrhoeae strains with mosaic penA alleles associated with decreased susceptibility and resistance to extended-spectrum cephalosporins. From 2012 through 2017, the proportion of mosaic penA alleles in gonococcal-positive nucleic acid amplification test (NAAT) specimens across South Korea increased from 1.1% to 23.9%. Gonococcal strains with mosaic penA alleles emerged in the international hubs of Seoul in Gyeonggi Province and Busan in South Gyeongsang Province and subsequently spread across South Korea. Most common was mosaic penA-10.001 (n = 572 isolates; 94.7%), which is associated with cefixime resistance. We also identified mosaic penA-34.001 and penA-60.001, both of which are associated with multidrug-resistant gonococcal strains and spread of cefixime and ceftriaxone resistance. Implementation of molecular resistance prediction from N. gonorrhoeae-positive nucleic acid amplification test specimens is imperative in South Korea and internationally.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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