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Long-term follow-up in patients treated with electrochemotherapy for non-melanoma skin cancer in the head and neck area
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- Kristiansson, Stefan (author)
- Department of Otolaryngology, Örebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital, Örebro, Sweden
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- Reizenstein, Johan (author)
- Department of Otolaryngology, Örebro Universitet Institutionen for Medicinska Vetenskaper, Örebro University Hospital, Örebro, Sweden
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- Von Beckerath, Mathias, 1966- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Otolaryngology
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- (creator_code:org_t)
- 2019-02-08
- 2019
- English.
- In: Acta Oto-Laryngologica. - : Taylor & Francis Group. - 0001-6489 .- 1651-2251. ; 139:2, s. 195-200
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: Electrochemotherapy (ECT) is a cancer treatment modality where the intracellular accumulation of chemotherapeutic agents is enhanced by an applied electrical field.Aims/Objectives: To evaluate the long-term efficacy, safety and functional outcome after ECT treatment in high-risk non-melanoma skin cancer (NMSC) with curative intent.Materials and methods: Seven patients with SCC or BCC in the head and neck area were treated with ECT with intratumoral bleomycin administration.Results: Five patients were cured by ECT as a mono-modality treatment after a median 10-year follow-up period. Two patients had recurrences and/or persisting tumors after treatment that required salvage surgery and radiotherapy. In two patients, the eye was spared with no visual impairment. In another patient, full facial nerve function was spared.Conclusions: ECT can be a curative as well as an organ and function-sparing mono modality treatment in high-risk NMSC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oto-rhino-laryngologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Otorhinolaryngology (hsv//eng)
Keyword
- Electrochemotherapy
- non-melanoma skin cancer
- squamous cell carcinoma
- basal cell carcinoma
Publication and Content Type
- ref (subject category)
- art (subject category)
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