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Delivery and Retent...
Delivery and Retention of an Insulin Aerosol Produced by a New Jet Nebulizer
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- Jendle, Johan, 1963- (author)
- Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Karlberg, Bengt E. (author)
- Department of Internal Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Persliden, Jan (author)
- Department of Radiation Physics, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Franzén, Lennart (author)
- Department of Pathology, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Arborelius, Måns, Jr (author)
- Department of Clinical Physiology, Malmö General Hospital, Malmö, Sweden
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(creator_code:org_t)
- Mary Ann Liebert, 1995
- 1995
- English.
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In: Journal of Aerosol Medicine. - : Mary Ann Liebert. - 0894-2684 .- 1557-9026. ; 8:3, s. 243-254
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- UNLABELLED: This study describes the delivery and distribution of an aerosol generated by a jet nebulizer (MAXIN) in an experimental animal model. Anesthetised, intubated and ventilated piglets inhaled radiolabeled technetium diethylene-triamine-penta-acetic acid (99mTc-DTPA) through the endotracheal tube. The lungs were excised en bloc and scintigraphed, using a computerized gamma camera to evaluate the pattern of distribution. By nebulizing radiolabeled 125I-insulin and comparing the activity deposited on inspiratory and expiratory electrostatic filters, delivery and retention of nebulized insulin was assessed. The distribution of aerosol in the lungs was very even and reached the most peripheral parts. The delivery of nebulized insulin was calculated to be 88.9 +/- 5.3% and 36.1 +/- 8.8% of the insulin delivered to the respiratory tract was retained. The immediate local effects of insulin aerosol administration on the lungs were evaluated using light microscopy. No adverse effects were observed at histopathologic examination of the lung tissue.CONCLUSION: This study shows a high penetration of aerosol to the peripheral parts of the lung and efficient delivery of nebulized insulin when using the MAXIN-nebulizer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Insulin
- aerosol
- retention
- delivery
- SPECT
- animal anesthesia
Publication and Content Type
- ref (subject category)
- art (subject category)
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