Molecular epidemiology of Staphylococcus epidermidis in prosthetic joint infections

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Månsson, Emeli,1978-Örebro universitet,Institutionen för medicinska vetenskaper (author)

Molecular epidemiology of Staphylococcus epidermidis in prosthetic joint infections

BookEnglish2019

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Örebro :Örebro University,2019
137 s.
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:oru-76142
ISBN:9789175293097
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-76142URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:vet swepub-contenttype
Subject category:dok swepub-publicationtype

Series

Örebro Studies in Medicine,1652-4063 ;203

Notes

Staphylococcus epidermidis is ubiquitous in the human microbiota, but also an important pathogen in healthcare-associated infections, such as prosthetic joint infections (PJIs). In this thesis, aspects of the molecular epidemiology of S. epidermidis in PJIs were investigated with the aim of improving our understanding of the pre- and perioperative measures required to reduce the incidence of S. epidermidis PJIs.In Paper I, S. epidermidis retrieved from air sampling in the operating field during arthroplasty was characterized by multilocus sequence typing and antibiotic susceptibility testing. No isolates belonging to sequence types (STs) 2 and 215, previously associated with PJIs, were found in the air of the operating field. During air sampling, several Staphylococcus pettenkoferi isolates were identified, and as a spin-off of Paper I, the genomic relatedness of these isolates to S. pettenkoferi isolates from blood cultures was described in Paper II.In Paper III, genetic traits distinguishing S. epidermidis isolated from PJIs were determined using genome-wide association study accounting for population effects after whole-genome sequencing (WGS) of a population- based 10-year collection of S. epidermidis isolates from PJIs and of nasal isolates retrieved from patients scheduled for arthroplasty. Genes associated with antimicrobial agents used for prophylaxis in arthroplasty, i.e., beta-lactam antibiotics, aminoglycosides, and chlorhexidine, were associated with PJI origin. S. epidermidis from PJIs were dominated by the ST2a, ST2b, ST5, and ST215 lineages.In Paper IV, selective agar plates were used to investigate colonization with methicillin resistant S. epidermidis (MRSE) in patients scheduled for arthroplasty. MRSE were further characterized by WGS. A subset of patients was found to harbour PJI-associated S. epidermidis lineages in their microbiota before hospitalization, but no isolates belonging to the ST2a lineage nor any rifampicin-resistant isolates were retrieved.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Infektionsmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Infectious Medicine hsv//eng
Staphylococcus epidermidis
molecular epidemiology
prosthetic joint infections
whole genome sequencing
Staphylococcus pettenkoferi

Added entries (persons, corporate bodies, meetings, titles ...)

Söderquist, Bo,professor,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)bost (thesis advisor)
Sundqvist, Martin,med. dr.1974-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län(Swepub:oru)mist (thesis advisor)
Nilsdotter-Augustinsson, Åsa,docentLinköping University, Norrköping, Sweden (thesis advisor)
Särndahl, Eva,professor,1963-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)easl (thesis advisor)
Bergh, Kåre,professorDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway (opponent)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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