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Dynamic Response Ge...
Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis
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- Hellberg, Sandra (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Eklund, Daniel, 1984- (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Gawel, Danuta (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Köpsén, Mattias (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Bioinformatik,Tekniska fakulteten,Ctr Individualised Medicine
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- Zhang, Huan (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Nestor, Colm (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Kockum, Ingrid (author)
- Karolinska Institutet,Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden
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- Olsson, Tomas (author)
- Karolinska Institutet,Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden
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- Skogh, Thomas (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Sjöwall, Christopher (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Vrethem, Magnus (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
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- Håkansson, Irene (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Benson, Mikael (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Allergicentrum US
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- Jenmalm, Maria (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
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- Gustafsson, Mika (author)
- Linköpings universitet,Bioinformatik,Tekniska fakulteten
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- Ernerudh, Jan (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin
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(creator_code:org_t)
- Cell Press, 2016
- 2016
- English.
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In: Cell Reports. - : Cell Press. - 2211-1247. ; 16:11, s. 2928-2939
- Related links:
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Abstract
Subject headings
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- Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS and has a varying disease course as well as variable response to treatment. Biomarkers may therefore aid personalized treatment. We tested whether in vitro activation of MS patient-derived CD4+ T cells could reveal potential biomarkers. The dynamic gene expression response to activation was dysregulated in patient-derived CD4+ T cells. By integrating our findings with genome-wide association studies, we constructed a highly connected MS gene module, disclosing cell activation and chemotaxis as central components. Changes in several module genes were associated with differences in protein levels, which were measurable in cerebrospinal fluid and were used to classify patients from control individuals. In addition, these measurements could predict disease activity after 2 years and distinguish low and high responders to treatment in two additional, independent cohorts. While further validation is needed in larger cohorts prior to clinical implementation, we have uncovered a set of potentially promising biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Hellberg, Sandra
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Eklund, Daniel, ...
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Gawel, Danuta
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Köpsén, Mattias
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Zhang, Huan
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Nestor, Colm
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show more...
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Kockum, Ingrid
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Olsson, Tomas
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Skogh, Thomas
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Kastbom, Alf
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Sjöwall, Christo ...
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Vrethem, Magnus
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Håkansson, Irene
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Benson, Mikael
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Jenmalm, Maria
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Gustafsson, Mika
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Ernerudh, Jan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Cell Reports
- By the university
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Örebro University
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Karolinska Institutet
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Linköping University