Search: onr:"swepub:oai:DiVA.org:oru-77102" >
Dynamic Response Ge...
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Hellberg, SandraLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten
(author)
Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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Cell Press,2016
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-77102
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-77102URI
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https://doi.org/10.1016/j.celrep.2016.08.036DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134223343URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-132056URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [K2013-61X-22310-01-4, K2013-61X-07488-28-5, 2015-03495]; Medical Research Council of Southeast Sweden (FORSS); Swedish Foundation for MS Research; NEURO Sweden; Centre for Industrial IT (CENIIT); Ake Wiberg Foundation; Knut and Alice Wallenberg Foundation; Swedish Brain Foundation; AFA foundation; Margareta af Ugglas foundation; Swedish Society for Medical Research; Biogen; Novartis; Genzyme; Merck; Allmiral; Biogen Idec
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Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS and has a varying disease course as well as variable response to treatment. Biomarkers may therefore aid personalized treatment. We tested whether in vitro activation of MS patient-derived CD4+ T cells could reveal potential biomarkers. The dynamic gene expression response to activation was dysregulated in patient-derived CD4+ T cells. By integrating our findings with genome-wide association studies, we constructed a highly connected MS gene module, disclosing cell activation and chemotaxis as central components. Changes in several module genes were associated with differences in protein levels, which were measurable in cerebrospinal fluid and were used to classify patients from control individuals. In addition, these measurements could predict disease activity after 2 years and distinguish low and high responders to treatment in two additional, independent cohorts. While further validation is needed in larger cohorts prior to clinical implementation, we have uncovered a set of potentially promising biomarkers.
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Eklund, Daniel,1984-Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)danek14
(author)
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Gawel, DanutaLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten(Swepub:liu)danga10
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Köpsén, MattiasLinköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Bioinformatik,Tekniska fakulteten,Ctr Individualised Medicine
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Zhang, HuanLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten(Swepub:liu)huazh47
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Nestor, ColmLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten(Swepub:liu)colne37
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Kockum, IngridKarolinska Institutet,Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden
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Olsson, TomasKarolinska Institutet,Karolinska Institute, Department Clin Neurosci, Neuroimmunol Unit, S-17177 Linkoping, Sweden
(author)
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Skogh, ThomasLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)thosk00
(author)
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Kastbom, AlfLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)alfka05
(author)
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Sjöwall, ChristopherLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland(Swepub:liu)chrsj93
(author)
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Vrethem, MagnusLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping(Swepub:liu)magvr07
(author)
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Håkansson, IreneLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)ireha53
(author)
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Benson, MikaelLinköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Allergicentrum US(Swepub:liu)mikbe05
(author)
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Jenmalm, MariaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten(Swepub:liu)marje18
(author)
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Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75
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Ernerudh, JanLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15
(author)
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Linköpings universitetAvdelningen för neuro- och inflammationsvetenskap
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In:Cell Reports: Cell Press16:11, s. 2928-29392211-1247
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Hellberg, Sandra
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Eklund, Daniel, ...
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Gawel, Danuta
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Köpsén, Mattias
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Zhang, Huan
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Nestor, Colm
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Kockum, Ingrid
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Olsson, Tomas
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Skogh, Thomas
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Kastbom, Alf
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Sjöwall, Christo ...
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Vrethem, Magnus
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Håkansson, Irene
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Benson, Mikael
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Jenmalm, Maria
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Gustafsson, Mika
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Ernerudh, Jan
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Örebro University
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Karolinska Institutet
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Linköping University