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Antimicrobial resis...
Antimicrobial resistance (AMR) and molecular characterization of Neisseria gonorrhoeae in Ghana, 2012-2015
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- Attram, Naiki (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
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- Agbodzi, Bright (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
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- Dela, Helena (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
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- Behene, Eric (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
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- Nyarko, Edward O. (author)
- Department of Public Health, Military Hospital, Accra, Ghana
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- Kyei, Nicholas N. A. (author)
- Department of Public Health, Military Hospital, Accra, Ghana
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- Larbi, John A. (author)
- Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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- Lawson, Bernard W. L. (author)
- Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
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- Addo, Kennedy K. (author)
- Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
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- Newman, Mercy J. (author)
- Department of Medical Microbiology, School of Biomedical and Allied Health Science, College of Health Sciences, University of Ghana, Accra, Ghana
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- Duplessis, Christopher A. (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana
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- Adams, Nehkonti (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana
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- Unemo, Magnus, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine
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- Letizia, Andrew G. (author)
- US Naval Medical Research Unit Number Three, Ghana Laboratory, Legon, Ghana
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(creator_code:org_t)
- 2019-10-10
- 2019
- English.
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In: PLOS ONE. - : PLOS. - 1932-6203. ; 14:10
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Abstract
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- Neisseria gonorrhoeae antimicrobial resistance (AMR) surveillance is essential for tracking the emergence and spread of AMR strains in local, national and international populations. This is crucial for developing or refining treatment guidelines. N. gonorrhoeae multiantigen sequence typing (NG-MAST) is beneficial for describing the molecular epidemiology of gonococci at national and international levels. Elucidation of AMR determinants to β-lactam drugs, is a means of monitoring the development of resistance. In Ghana, little is known about the current gonococcal AMR prevalence and no characterization of gonococcal isolates has been previously performed. In this study, gonococcal isolates (n = 44) collected from five health facilities in Ghana from 2012 to 2015, were examined using AMR testing, NG-MAST and sequencing of penA. High rates of resistance were identified to tetracycline (100%), benzylpenicillin (90.9%), and ciprofloxacin (81.8%). One isolate had a high cefixime MIC (0.75 μg/ml). Twenty-eight NG-MAST sequence types (STs) were identified, seventeen of which were novel. The isolate with the high cefixime MIC contained a mosaic penA-34 allele and belonged to NG-MAST ST1407, an internationally spreading multidrug-resistant clone that has accounted for most cefixime resistance in many countries. In conclusion, AMR testing, NG-MAST, and sequencing of the AMR determinant penA, revealed high rates of resistance to tetracycline, benzylpenicillin, and ciprofloxacin; as well as a highly diverse population of N. gonorrhoeae in Ghana. It is imperative to continue with enhanced AMR surveillance and to understand the molecular epidemiology of gonococcal strains circulating in Ghana and other African countries.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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- ref (subject category)
- art (subject category)
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Attram, Naiki
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Agbodzi, Bright
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Dela, Helena
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Behene, Eric
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Nyarko, Edward O ...
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Kyei, Nicholas N ...
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Larbi, John A.
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Lawson, Bernard ...
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Addo, Kennedy K.
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Newman, Mercy J.
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Duplessis, Chris ...
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Adams, Nehkonti
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Unemo, Magnus, 1 ...
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Letizia, Andrew ...
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- MEDICAL AND HEALTH SCIENCES
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Örebro University