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Beta-blocker use an...
Beta-blocker use and lung cancer mortality in a nationwide cohort study of patients with primary non-small cell lung cancer
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- Udumyan, Ruzan, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics
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- Montgomery, Scott, 1961- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics
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- Fang, Fang (author)
- Karolinska Institutet
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- Valdimarsdóttir, Unnur (author)
- Karolinska Institutet
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- Hardardottir, Hronn (author)
- Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik, Iceland
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- Ekbom, Anders (author)
- Karolinska Institutet
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Fall, Katja, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology & Biostatistics, Karolinska Institute, Stockholm, Sweden,Clinical Epidemiology and Biostatistics
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(creator_code:org_t)
- Prevention American Association for Cancer Research, 2019
- 2019
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : Prevention American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 29:1, s. 119-126
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Beta-adrenergic receptor blockers have been associated with improved survival among patients with different types of malignancies, but available data for non-small cell lung cancer (NSCLC) patients is contradictory and limited to small hospital-based studies. We therefore aimed to investigate if β-blocker use at the time of cancer diagnosis is associated with lung cancer mortality in the largest general population-based cohort of patients with NSCLC to date.PATIENTS AND METHODS: For this retrospectively defined nationwide cohort study, we used prospectively collected data from Swedish population and health registers. Through the Swedish Cancer Register, we identified 18,429 patients diagnosed with a primary NSCLC between 2006 and 2014 with follow-up to 2015. Cox regression was used to estimate the association between beta-blocker use at time of cancer diagnosis ascertained from the Prescribed Drug Register and cancer-specific mortality identified from the Cause of Death Register.RESULTS: Over a median follow-up of 10.2 months, 14,994 patients died (including 13,398 from lung cancer). Compared with non-use, beta-blocker use (predominantly prevalent use, 93%) was not associated with lung cancer mortality [hazard ratio (95% confidence interval): 1.01 (0.97-1.06)]. However, the possibility that diverging associations for specific beta-blockers and some histopathological subtypes exist cannot be excluded.CONCLUSION: In this nationwide cohort of NSCLC patients, beta-blocker use was not associated with lung cancer mortality when assessed in aggregate in the total cohort, but evidence for some beta-blockers is less conclusive.IMPACT: Our results do not indicate that beta-blocker use at lung cancer diagnosis reduces the cancer-specific mortality rate in NSCLC patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Udumyan, Ruzan, ...
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Montgomery, Scot ...
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Fang, Fang
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Valdimarsdóttir, ...
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Hardardottir, Hr ...
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Ekbom, Anders
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Smedby, Karin E.
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Fall, Katja, 197 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Örebro University
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Karolinska Institutet