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Tissue distribution...
Tissue distribution of C-14-labelled perfluorooctanoic acid in adult mice after 1-5 days of dietary exposure to an experimental dose or a lower dose that resulted in blood levels similar to those detected in exposed humans
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- Bogdanska, Jasna (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden
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- Borg, Daniel (author)
- Swedish Chemicals Agency, Stockholm, Sweden,Swedish Chem Agcy, SE-17267 Stockholm, Sweden
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- Bergström, Ulrika (author)
- Uppsala universitet,Miljötoxikologi
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- Mellring, Maria (author)
- Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi,Stockholm Univ, Dept Analyt Chem & Environm Sci, SE-10691 Stockholm, Sweden;Dept Clin Chem, Aleris Medilab, SE-18515 Taby, Sweden
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- Bergman, Åke, 1950- (author)
- Stockholms universitet,Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Analytical Chemistry and Environmental Science, Stockholm University, Stockholm, Sweden,Institutionen för miljövetenskap och analytisk kemi,Stockholm Univ, Dept Analyt Chem & Environm Sci, SE-10691 Stockholm, Sweden;Orebro Univ, Sch Sci & Technol, SE-70182 Orebro, Sweden
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- DePierre, Joseph (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, SE-10691 Stockholm, Sweden
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- Nobel, Stefan (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Chemosphere. - : Elsevier. - 0045-6535 .- 1879-1298. ; 239
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Abstract
Subject headings
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- Perfluorooctanoic acid (PFOA), a global environmental pollutant detected in both wildlife and human populations, has several pathophysiological effects in experimental animals, including hepatotoxicity, immunotoxicity, and developmental toxicity. However, details concerning the tissue distribution of PFOA, in particular at levels relevant to humans, are lacking, which limits our understanding of how humans, and other mammals, may be affected by this compound. Therefore, we characterized the tissue distribution of C-14-PFOA in mice in the same manner as we earlier examined its analogues perfluorooctanesulfonate (PFOS) and perfluorobutanesulfonate (PFBS) in order to allow direct comparisons. Following dietary exposure of adult male C57/BL6 mice for 1, 3 or 5 days to a low dose (0.06 mg/kg/day) or a higher experimental dose (22 mg/kg/day) of C-14-PFOA, both scintillation counting and whole-body autoradiography revealed the presence of PFOA in most of the 19 different tissues examined, demonstrating its ability to leave the bloodstream and enter tissues. There were no differences in the pattern of tissue distribution with the low and high dose and the tissue-to-blood ratios were similar. At both doses, PFOA levels were highest in the liver, followed by blood, lungs and kidneys. The body compartments estimated to contain the largest amounts of PFOA were the liver, blood, skin and muscle. In comparison with our identical studies on PFOS and PFBS, PFOA reached considerably higher tissue levels than PFBS, but lower than PFOS. Furthermore, the distribution of PFOA differed notably from that of PFOS, with lower tissue-to-blood ratios in the liver, lungs, kidneys and skin.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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