Delineating physiologic defensive reactivity in the domain of self report: Phenotypic and etiologic structure of dispositional fear

Kramer, Mark,1973-University of Minnesota – Twin Cities, Minneapolis MN, USA (author)

Delineating physiologic defensive reactivity in the domain of self report : Phenotypic and etiologic structure of dispositional fear

Funding Agencies:Minnesota Center for Twin and Family Research United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) MH65137 MH072850 MH089727
Background: Individual differences in fear and fearlessness have been investigated at their extremes in relation to markedly different forms of psychopathology - anxiety disorders and psychopathy, respectively. A documented neural substrate of fear-related traits and disorders is defensive reactivity as reflected in aversive startle potentiation (ASP).Method: The current study extended prior work by characterizing, in a sample of adult twins from the community (n=2511), the phenotypic and etiologic structure of self-report measures of fear and fearlessness known to be associated with ASP.Results: Analyses revealed a hierarchical structure to the trait fear domain, with an overarching, bipolar fear/fearlessness dimension saturating each measure in this domain, and subfactors labeled 'distress,' 'stimulation seeking' and 'sociability' accounting for additional variance in particular measures. The structure of genetic and non-shared environmental associations among the measures closely mirrored the phenotypic structure of the domain.Conclusions: The findings have implications for proposals to reconceptualize psychopathology in neurobiological terms.

Patrick, C. J.Florida State University, Department of Psychology, Tallahassee FL, USA (author)
Krueger, R. F.University of Minnesota – Twin Cities, Minneapolis MN, USA (author)
Gasperi, MUniversity of Minnesota – Twin Cities, Minneapolis MN, USA (author)
University of Minnesota – Twin Cities, Minneapolis MN, USAFlorida State University, Department of Psychology, Tallahassee FL, USA (creator_code:org_t)

In:Psychological Medicine: Cambridge University Press42:6, s. 1305-13200033-29171469-8978

By the author/editor: Kramer, Mark, 19 ...; Patrick, C. J.; Krueger, R. F.; Gasperi, M

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