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Pulmonary phthalate...
Pulmonary phthalate exposure and asthma - is PPAR a plausible mechanistic link?
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- Bölling, Anette (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Holme, Jörn (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Bornehag, Carl-Gustaf, 1957- (author)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
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- Nygaard, Unni C (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Bertelsen, Randi (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Nånberg, Eewa, 1957- (author)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013)
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- Bodin, Johanna (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Sakhi, Amrit Kaur (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Thomsen, Cathrine (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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- Becher, Rune (author)
- Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
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(creator_code:org_t)
- Universität Mainz, 2013
- 2013
- English.
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In: EXCLI Journal. - : Universität Mainz. - 1611-2156. ; 12, s. 733-759
- Related links:
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https://www.excli.de...
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Due to their extensive use as plasticisers in numerous consumer products, phthalates have become ubiquitous environmental contaminants. An increasing number of epidemiological studies suggest that exposure to phthalates may be associated with worsening or development of airway diseases. Peroxisome Proliferation Activated Receptors (PPAR)s, identified as important targets for phthalates in early studies in rodent liver, have been suggested as a possible mechanistic link. In this review we discuss the likelihood of an involvement of PPARs in asthma development and exacerbation due to pulmonary phthalate exposure. First, we go through the literature on indoor air levels of phthalates and pulmonary phthalate kinetics. These data are then used to estimate the pulmonary phthalate levels due to inhalation exposure. Secondly, the literature on phthalate-induced activation or modulation of PPARs is summarized. Based on these data, we discuss whether pulmonary phthalate exposure is likely to cause PPAR activation, and if this is a plausible mechanism for adverse effects of phthalates in the lung. It is concluded that the pulmonary concentrations of some phthalates may be sufficient to cause a direct activation of PPARs. Since PPARs mainly mediate antiinflammatory effects in the lungs, a direct activation is not a likely molecular mechanism for adverse effects of phthalates. However, possible modulatory effects of phthalates on PPARs deserve further investigation, including partial antagonist effects and/or cross talk with other signalling pathways. Moreover other mechanisms, including interactions between phthalates and other receptors, could also contribute to possible adverse pulmonary effects of phthalates.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Phthalates
- asthma
- Peroxisome Proliferation Activated Receptors
- molecular mechanism
- Public Health Science
- Folkhälsovetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bölling, Anette
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Holme, Jörn
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Bornehag, Carl-G ...
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Nygaard, Unni C
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Bertelsen, Randi
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Nånberg, Eewa, 1 ...
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show more...
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Bodin, Johanna
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Sakhi, Amrit Kau ...
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Thomsen, Cathrin ...
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Becher, Rune
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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EXCLI Journal
- By the university
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Örebro University
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Karlstad University