Differentiation and survival influences of growth factors in human neuroblastoma

Hoehner, J.C. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Nånberg, E., 1957- (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden,Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för genetik och patologi

Hedborg, F. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Fagerström, S. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Gestblom, C. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Johansson, I. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Larsson, U. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Lavenius, E. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

Örtoft, E. (author): Department of Pathology, University Hospital, Uppsala University, Uppsala, Sweden

(creator_code:org_t)

Elsevier, 1995
1995
English.
In: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 31A:4, s. 453-458

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Human neuroblastoma cell lines are established from high-stage, highly malignant tumours. Despite this and the fact that these tumours are arrested at an early, immature stage, many cell lines have the capacity to undergo neuronal differentiation under proper growth conditions. One such cell line is the noradrenergic SH-SY5Y cell line. These cells can be induced to mature by a variety of modalities, resulting in different mature phenotypes. The use of this cell system as a model to study the stem cell character of neuroblastoma is reviewed and discussed. In particular, we focus on growth factor dependencies in the SH-SY5Y system, and compare that to the normal situation, i.e. growth factor control of sympathetic neuronal and neuroendocrine differentiation during human and rat embryogenesis.

By the author/editor: Påhlman, S.; Hoehner, J.C.; Nånberg, E., 195 ...; Hedborg, F.; Fagerström, S.; Gestblom, C.; show more...; Johansson, I.; Larsson, U.; Lavenius, E.; Örtoft, E.; Kaihola, Helena; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

By the university: Örebro University; Uppsala University; Karlstad University

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