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Validation of serra...
Validation of serrated polyps (SPs) in Swedish pathology registers
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- Bozorg, Soran R., 1993- (author)
- Karolinska Institutet
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- Song, Mingyang (author)
- Department of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston MA, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States
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- Emilsson, Louise (author)
- Karolinska Institutet
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, United States
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Karolinska Institutet Department of Epidemiology and Nutrition, Harvard TH. Chan School of Public Health, Boston MA, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston MA, United States (creator_code:org_t)
- 2019-12-31
- 2019
- English.
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In: BMC Gastroenterology. - : BMC. - 1471-230X. ; 20:1
- Related links:
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https://doi.org/10.1...
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https://bmcgastroent...
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https://urn.kb.se/re...
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Abstract
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- Background: Little is known about the natural history of serrated polyps (SPs), partly due to the lack of large-scale epidemiologic data. In this study, we examined the validity of SP identification according to SNOMED (Systematised Nomenclature of Medicine) codes and free text from colorectal histopathology reports.Methods: Through the ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) study, we retrieved data on SPs from all pathology departments in Sweden in 2015-2017 by using SNOMED codes and free-text search in colorectal histopathology reports. Randomly selected individuals with a histopathology report of SPs were validated against patient charts using a structured, retrospective review.Results: SPs were confirmed in 101/106 individuals with a histopathology report of SPs, yielding a positive predictive value (PPV) of 95% (95%CI = 89-98%). By year of diagnosis, the PPV was 89% (95%CI = 69-97%), 96% (95%CI = 81-99%) and 97% (95%CI = 89-99%) for individuals diagnosed before 2001 (n = 19), between 2001 and 2010 (n = 26) and after 2010 (n = 61), respectively. According to search method, the PPV for individuals identified by SNOMED codes was 100% (95%CI = 93-100%), and 93% (95%CI = 86-97%) using free-text search. Recorded location (colon vs. rectum) was correct in 94% of all SP histopathology reports (95%CI = 84-98%) identified by SNOMED codes. Individuals with SPs were classified into hyperplastic polyps (n = 34; 32%), traditional serrated adenomas (n = 3; 3%), sessile serrated adenomas/polyps (SSA/Ps) (n = 70; 66%), unspecified SPs (n = 3, 3%), and false positive SPs (n = 5, 5%). For individuals identified by SNOMED codes, SSA/Ps were confirmed in 49/52 individuals, resulting in a PPV of 94% (95%CI: 84-98%). In total, 57% had >= 2 polyps (1: n = 44, 2-3: n = 33 and >= 4: n = 27). Some 46% of SPs (n = 71) originated from the proximal colon and 24% were >= 10 mm in size (n = 37). Heredity for colorectal cancer, intestinal polyposis syndromes, or both was reported in seven individuals (7%). Common comorbidities included diverticulosis (n = 45, 42%), colorectal cancer (n = 19, 18%), and inflammatory bowel disease (n = 10, 9%).Conclusion: Colorectal histopathology reports are a reliable data source to identify individuals with SPs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Hyperplastic polyp
- Serrated adenoma
- Serrated polyp
- Sessile serrated adenoma
- polyp
- Traditional serrated adenoma
- Validation
Publication and Content Type
- ref (subject category)
- art (subject category)
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