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Reduced prostagland...
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Vedin, IngerKarolinska Institutet
(author)
Reduced prostaglandin F-2 alpha release from blood mononuclear leukocytes after oral supplementation of omega 3 fatty acids : the OmegAD study
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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American Society for Biochemistry and Molecular Biology,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-79168
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79168URI
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https://doi.org/10.1194/jlr.M002667DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122887URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120310195URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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This study was supported by Swedish Medical Research Council Grants 19X-05991 and 71XS-13135. This study was also supported by funding from the Swedish Association against Rheumatism; Karolinska Institutet; Huddinge University Hospital; the Funds of Å Wiberg; King Gustaf V:s 80-year; Uggla; N Svartz; Vårdal; Swedish Cancer Society; Cancer Society of Stockholm; Swedish Alzheimer Foundation; and the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and the Karolinska Institutet. Clinical Trials. Gov Identifier: NCT00211159.
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Omega-3 fatty acids, e. g., dokosahexaenoic acid (DHA) and eikosapentaenoic acid (EPA), ameliorate inflammatory reactions by various mechanisms, but the role of prostaglandins remains unclear. Our aim was to determine if dietary supplementation with a DHA-rich fish oil influenced the release of PGF(2 alpha) from peripheral blood mononuclear cells (PBMC). In the OmegAD study, 174 Alzheimer disease patients received either 1.7 g DHA plus 0.6 g EPA or a placebo daily for six months. PBMCs from the 21 ( 9 on fish oil and 12 on placebo) first-randomized patients were stimulated with either lipopolysaccharide (LPS) or phytohemagglutinin (PHA) before and after 6 months. Our results showed that plasma concentrations of DHA and EPA increased significantly at 6 months in the omega-3 group. PGF(2 alpha) release from LPS- ( but not from PHA-) stimulated PBMC was significantly diminished in this group; no change was noted in the placebo group. PGF(2 alpha) changes correlated inversely with changes in plasma DHA and EPA. Decreased IL-6 and IL-1(beta) levels correlated with decreased PGF(2 alpha) levels. The stimulus-specific PGF(2 alpha) release from PBMC after 6 months of oral supplementation with the DHA-rich fish oil might be one event related to reduced inflammatory reactions associated with omega-3 fatty acid intake.
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Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419
(author)
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Freund-Levi, Yvonne,1956-Department of Neurobiology, Caring Sciences and Society, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden(Swepub:oru)yfi
(author)
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Basun, HansUppsala universitet,Geriatrik(Swepub:uu)habas169
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Hjorth, ErikKarolinska Institutet
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Faxén Irving, GerdKarolinska Institutet
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Eriksdotter-Jönhagen, MariaKarolinska Institutet
(author)
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Schultzberg, MarianneKarolinska Institutet
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Wahlund, Lars-OlofKarolinska Institutet
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Palmblad, JanKarolinska Institutet
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Karolinska InstitutetKlinisk nutrition och metabolism
(creator_code:org_t)
Related titles
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In:Journal of Lipid Research: American Society for Biochemistry and Molecular Biology51:5, s. 1179-11850022-22751539-7262
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