Increased inflammasome activity in markedly ill psychiatric patients: An explorative study

Increased inflammasome activity in markedly ill psychiatric patients : An explorative study

Hylén, Ulrika, 1977- (author): Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden

Eklund, Daniel, 1984- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden

Humble, Mats B., 1952- (author): Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden

Bartoszek, Jakub (author): School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

Särndahl, Eva, 1963- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden

Bejerot, Susanne, 1955- (author): Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Sweden; Inflammatory Response and Infection Susceptibility Centre, (iRiSC), Örebro University, Örebro, Sweden

(creator_code:org_t)

Elsevier, 2020
2020
English.
In: Journal of Neuroimmunology. - : Elsevier. - 0165-5728 .- 1872-8421. ; 339

Related links:: https://doi.org/10.1...; show more...; http://www.jni-journ...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

The aim of this study was to investigate inflammatory perturbations in 40 patients with severe and complex psychiatric disorders by studying the activity of the NLRP3 inflammasome, with a trans-diagnostic approach. Gene expression of CASP1, NLRP3, PYCARD, IL1B, IL1RN, TNF showed a significant increase in the patient group compared to a matched control group. Plasma levels of IL1Ra, IL-18, TNF, IL-6 and CRP were increased in the patient group. Within the patient group, increased gene expression of inflammatory markers correlated with increased disease severity. The findings support the inflammation hypothesis for markedly ill psychiatric patients across diagnostic groups.

By the author/editor: Hylén, Ulrika, 1 ...; Eklund, Daniel, ...; Humble, Mats B., ...; Bartoszek, Jakub; Särndahl, Eva, 1 ...; Bejerot, Susanne ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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