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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00011255naa a2201033 4500
001oai:DiVA.org:oru-79728
003SwePub
008200203s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:143257872
009oai:gup.ub.gu.se/291090
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-797282 URI
0247 a https://doi.org/10.3233/JAD-1904342 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1432578722 URI
0247 a https://gup.ub.gu.se/publication/2910902 URI
040 a (SwePub)orud (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Westwood, Sarahu Department of Psychiatry, University of Oxford, UK4 aut
2451 0a Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort
264 1b IOS Press,c 2020
338 a print2 rdacarrier
520 a We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer’s disease
653 a amyloid-β
653 a biomarkers
653 a plasma
653 a proteomics
7001 a Baird, Alison L.u Department of Psychiatry, University of Oxford, UK4 aut
7001 a Anand, Sneha N.u Department of Psychiatry, University of Oxford, UK4 aut
7001 a Nevado-Holgado, Alejo J.u Department of Psychiatry, University of Oxford, UK4 aut
7001 a Kormilitzin, Andreyu Department of Psychiatry, University of Oxford, UK4 aut
7001 a Shi, Liuu Department of Psychiatry, University of Oxford, UK4 aut
7001 a Hye, Abdulu Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK4 aut
7001 a Ashton, Nicholas J.u Gothenburg University,Göteborgs universitet,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xashtn
7001 a Morgan, Angharad R.u Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK4 aut
7001 a Bos, Isabelleu Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Vos, Stephanie J. B.u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Baker, Susanu Janssen R&D, Titusville, NJ, USA4 aut
7001 a Buckley, Noel J.u Department of Psychiatry, University of Oxford, UK4 aut
7001 a Ten Kate, Marau Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut
7001 a Scheltens, Philipu Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut
7001 a Teunissen, Charlotte E.u Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut
7001 a Vandenberghe, Riku University Hospital Leuven, Leuven, Belgium4 aut
7001 a Gabel, Silvyu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium4 aut
7001 a Meersmans, Karenu University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium4 aut
7001 a Engelborghs, Sebastiaanu Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium4 aut
7001 a De Roeck, Ellen E.u Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, University of Antwerp, Antwerp, Belgium; Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium4 aut
7001 a Sleegers, Kristelu Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Belgium4 aut
7001 a Frisoni, Giovanni B.u University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy4 aut
7001 a Blin, Olivieru AIX Marseille University, INS, Ap-Hm, Marseille, France4 aut
7001 a Richardson, Jill C.u Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK4 aut
7001 a Bordet, Régisu University of Lille, Inserm, CHU Lille, France4 aut
7001 a Molinuevo, José L.u Alzheimer's Disease & Other Cognitive Disorders Unit, Hopsital Clínic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain4 aut
7001 a Rami, Lorenau Barcelona Beta Brain Research Center, Unversitat Pompeu Fabra, Barcelona, Spain4 aut
7001 a Wallin, Andersu Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden4 aut
7001 a Kettunen, Petronellau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xketpe
7001 a Tsolaki, Magdau 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece4 aut
7001 a Verhey, Fransu Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut
7001 a Lléo, Albertou Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut
7001 a Sala, Isabelu Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut
7001 a Popp, Juliusu Karolinska Institutet4 aut
7001 a Peyratout, Gwendolineu University Hospital of Lausanne, Lausanne, Switzerland4 aut
7001 a Martinez-Lage, Pablou Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland4 aut
7001 a Tainta, Mikelu CITA-Alzheimer Foundation, San Sebastian, Spain4 aut
7001 a Johannsen, Peteru Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark4 aut
7001 a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK4 aut0 (Swepub:oru)yfi
7001 a Frölich, Lutzu Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany4 aut
7001 a Dobricic, Valerijau Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany4 aut
7001 a Legido-Quigley, Cristinau Kings College London, London, UK; The Systems Medicine Group, Steno Diabetes Center, Gentofte, Denmark4 aut
7001 a Bertram, Larsu Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway4 aut
7001 a Barkhof, Frederiku Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherland; UCL Institutes of Neurology and Healthcare Engineering, London, UK4 aut
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
7001 a Morgan, B. Paulu Dementia Research Institute Cardiff, Cardiff University, Cardiff, UK4 aut
7001 a Streffer, Johannesu Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium; UCB, Braine-l'Alleud, Belgium, formerly Janssen R&D, LLC. Beerse, Belgium at the Time of Study Conduct4 aut
7001 a Visser, Pieter Jelleu Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut
7001 a Lovestone, Simonu Department of Psychiatry, University of Oxford, UK; Janssen R&D, UK4 aut
7102 a Department of Psychiatry, University of Oxford, UKb Maurice Wohl Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK4 org
7730 t Journal of Alzheimer's Diseased : IOS Pressg 74:1, s. 213-225q 74:1<213-225x 1387-2877x 1875-8908
8564 u https://doi.org/10.3233/JAD-190434y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79728
8564 8u https://doi.org/10.3233/JAD-190434
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:143257872
8564 8u https://gup.ub.gu.se/publication/291090

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