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Early life triclosa...
Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort
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- Guo, Jianqiu (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Wu, Chunhua (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Zhang, Jiming (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Xiao, Hongxi (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Lv, Shenliang (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Lu, Dasheng (author)
- Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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- Qi, Xiaojuan (author)
- Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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- Feng, Chao (author)
- Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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- Liang, Weijiu (author)
- Cangning District Center for Disease Control and Prevention, Shanghai, China
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- Chang, Xiuli (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Zhang, Yubin (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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- Xu, Hao (author)
- Changning District Center for Disease Control and Prevention, Shanghai, China
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- Cao, Yang, Associate Professor, 1972- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- Wang, Guoquan (author)
- Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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- Zhou, Zhijun (author)
- School of Public Health/ Key Laboratory of Public Health Safety of Ministry of Education/ Key Lab of Health Technology Assessment, National Health Commission of the People's Republic of China, Fudan University, Shanghai, China
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(creator_code:org_t)
- Urban & Fischer, 2020
- 2020
- English.
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In: International journal of hygiene and environmental health. - : Urban & Fischer. - 1438-4639 .- 1618-131X. ; 224
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Early life exposure to triclosan, an emerging endocrine disrupting chemical, may adversely impact childhood neurodevelopment, but limited epidemiologic studies have examined the associations.OBJECTIVE: We evaluated the associations between prenatal and postnatal triclosan exposure and child neurodevelopment at 3 years.METHODS: The study included 377 mother-child pairs who participated in Sheyang Mini Birth Cohort Study (SMBCS), a longitudinal birth cohort in China. Triclosan concentrations in maternal and 3-year-old child urine samples were quantified using gas chromatography-tandem mass spectrometry (GC-MS/MS). Gesell Developmental Schedules (GDS) were used to assess child neurodevelopment at 3 years of age. Multivariate linear regression models were applied to estimate associations of prenatal and postnatal urinary triclosan concentrations with children's developmental quotients (DQs).RESULTS: Detection frequencies of triclosan in maternal and childhood urine samples were 100% and 99.5%, respectively. The median values of prenatal and postnatal urinary triclosan levels were 0.65 and 0.44 μg/L, respectively. One ln-unit increase of maternal urinary triclosan concentration was associated with increase of DQ scores in motor area of children (regression coefficient, β = 0.28, 95% confidence interval, CI: 0.03, 0.54; p = 0.03). In sex-stratified analyses, maternal urinary triclosan levels were significantly related to increases in DQ scores in motor area among boys (β = 0.25, 95%CI: 0.01, 0.50; p = 0.04), while postnatal urinary triclosan concentrations were inversely associated with DQ scores in social area in boys (β = -0.37, 95%CI: -0.72, -0.03; p = 0.03).CONCLUSIONS: The findings suggested that prenatal triclosan exposure predicted increases in motor scores, while postnatal triclosan exposure was related to reductions in social scores of 3-year-old children. These associations were only observed in boys. The biological mechanisms linking triclosan exposure to neurodevelopment await further studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Biomonitoring
- Child neurodevelopment
- Prenatal and postnatal exposure
- Triclosan
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Guo, Jianqiu
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Wu, Chunhua
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Zhang, Jiming
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Xiao, Hongxi
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Lv, Shenliang
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Lu, Dasheng
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show more...
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Qi, Xiaojuan
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Feng, Chao
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Liang, Weijiu
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Chang, Xiuli
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Zhang, Yubin
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Xu, Hao
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Cao, Yang, Assoc ...
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Wang, Guoquan
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Zhou, Zhijun
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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International jo ...
- By the university
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Örebro University
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Karolinska Institutet