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  • Hadad, Ronza,1984-Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Microbiology (author)

A Chlamydia trachomatis 23S rRNA G1523A variant escaping detection in the Aptima Combo 2 assay (Hologic) was widespread across Denmark in July-September 2019

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-05-04
  • Wiley-Blackwell Publishing Inc.2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-80835
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-80835URI
  • https://doi.org/10.1111/apm.13043DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection globally, and nucleic acid amplification tests (NAATs) are recommended for highly sensitive and specific diagnosis. In early 2019, the Finnish new variant of Chlamydia trachomatis (FI-nvCT) was identified. The FI-nvCT has a C1515T mutation in the 23S rRNA gene, making it escaping detection in the Aptima Combo 2 (AC2; Hologic) NAAT, and the FI-nvCT has been subsequently reported in Sweden and Norway. In the present study, we investigated the presence of the FI-nvCT and other AC2 diagnostic-escape CT mutants in July-September 2019 in Denmark. The FI-nvCT was present but rare in Denmark. However, another AC2 diagnostic-escape CT mutant (with a 23S rRNA G1523A mutation) was found to be widespread across Denmark, accounting for 95% (76/80) of AC2 diagnostic-escape nvCT samples from five Danish CT-diagnostic laboratories. This nvCT-G1523A has previously only been detected in one single sample in the United Kingdom and Norway, respectively. It is vital to monitor the continued stability of the NAAT targets in local, national and international settings and monitor as well as appropriately analyse incidence, unexplained shifts in diagnostics rates, and/or annual collections of samples diagnosed as negative/equivocal using NAATs with different target(s). Furthermore, diagnostic CT NAATs with dual target sequences are crucial and fortunately, an updated Hologic AC2 assay including one additional target sequence is in advanced development.

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  • Skov Jensen, JørgenDepartment for Bacteria, Parasites and Fungi, Infectious Diseases Preparedness, Statens Serum Institut, Copenhagen, Denmark (author)
  • Westh, HenrikDepartment of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark (author)
  • Grønbaek, IdaDepartment of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark (author)
  • Jessen Schwartz, LasseDepartment for Bacteria, Parasites and Fungi, Infectious Diseases Preparedness, Statens Serum Institut, Copenhagen, Denmark (author)
  • Nielsen, LeneDepartment of Clinical Microbiology, Copenhagen University Hospital, Herlev, Denmark (author)
  • Müller Vang, TobiasDepartment of Clinical Microbiology, Copenhagen University Hospital, Herlev, Denmark (author)
  • Nielsen, RikkeDepartment of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark (author)
  • Sandborg Weinreich, LenetteDepartment of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark (author)
  • Skov, Marianne N.Department of Clinical Microbiology, Odense University Hospital, Odense, Denmark (author)
  • Olsen, MarleneDepartment of Clinical Microbiology, Odense University Hospital, Odense, Denmark (author)
  • Kjølseth Møller, JensDepartment of Clinical Microbiology, Vejle University Hospital, Vejle, Denmark (author)
  • Kolmos, BirteDepartment of Clinical Microbiology, Vejle University Hospital, Vejle, Denmark (author)
  • Unemo, Magnus,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Microbiology(Swepub:oru)muo (author)
  • Hoffmann, SteenDepartment for Bacteria, Parasites and Fungi, Infectious Diseases Preparedness, Statens Serum Institut, Copenhagen, Denmark (author)
  • Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Related titles

  • In:Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS): Wiley-Blackwell Publishing Inc.128:6, s. 440-4440903-46411600-0463

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