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Morphological chara...
Morphological characterization of the evolving rat spinal cord injury after photochemically induced ischemia
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- von Euler, Mia, 1967- (author)
- Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden
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- Sundström, E. (author)
- Karolinska Institutet
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- Seiger, A. (author)
- Karolinska Institutet
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- vonEuler, M (author)
- Karolinska Institutet
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(creator_code:org_t)
- Springer, 1997
- 1997
- English.
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In: Acta Neuropathologica. - : Springer. - 0001-6322 .- 1432-0533. ; 94:3, s. 232-239
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We have characterized the evolving morphological changes in the adult rat spinal cord following photochemically induced spinal cord ischemia. In cresyl violet-stained sections, disintegration of the tissue at the epicenter was evident at 6 h. This was preceded at 1 h post ischemia by an albumin immunoreactivity. The albumin immunoreactivity was increased at 6 and even more so at 24 h post ischemia. At 72 h post ischemia the albumin immunoreactivity was decreased. The size of the lesion was established by 3 days after the onset of ischemia. During the 1st week post ischemia, neurofilament (NF) immunohistochemistry showed swollen axons adjacent to the injured tissue. From 2 weeks post ischemia an increasing number of regrowing NF-immunoreactive axons could be seen in the center of the necrotic cavity. At 3 weeks after ischemia, a developing gliosis was observed around and rostral to the lesion cavity, as evidenced by increased glial fibrillary acidic protein (GFAP) immunoreactivity. The gliosis became more pronounced until 6 weeks post ischemia, at which time enlarged GFAP-immunoreactive cells could be seen in the remaining viable tissue bordering the necrotic areas. In this study we show that several traits in the development of a spinal cord lesion after photochemically induced ischemia are similar to those described previously after traumatic spinal cord lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Spinal cord ischemia
- Glial fibrillary
- acidic protein
- Neurofilament
- Albumin
- Immunohistochemistry
Publication and Content Type
- ref (subject category)
- art (subject category)
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