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NBQX, a competitive...
NBQX, a competitive non-NMDA receptor antagonist, reduces degeneration due to focal spinal cord ischemia
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- von Euler, Mia, 1967- (author)
- Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
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- Seiger, A. (author)
- Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
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- Holmberg, L. (author)
- Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
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- Sundström, E. (author)
- Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
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(creator_code:org_t)
- New York, USA : Academic Press, 1994
- 1994
- English.
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In: Experimental Neurology. - New York, USA : Academic Press. - 0014-4886 .- 1090-2430. ; 129:1, s. 163-168
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We have used the laser-induced photochemical thrombosis model in adult rats to evaluate the significance of the non-N-methyl-D-aspartate (non-NMDA) subtype of glutamate receptors in situations of focal spinal cord ischemia. The animals were pretreated with the selective non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX) or, for comparison, the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine (MK-801). Neurological function was quantified using evaluations of motor score and inclined plane. The MK-801-treated rats had higher motor scores during the 3-week observation period while NBQX-treated rats only performed significantly better at 1 week. Both treatments caused significantly better performance in the inclined plane test. NBQX and MK-801 reduced the volume of necrosis by approximately 47% at 3 weeks postlesion. We conclude that blockade of both NMDA and non-NMDA subtypes of glutamate receptors reduces ischemic necrosis, possibly by preventing excessive stimulation of these receptors by released excitatory amino acids in the lesion area.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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