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NBQX, a competitive...
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von Euler, Mia,1967-Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
(author)
NBQX, a competitive non-NMDA receptor antagonist, reduces degeneration due to focal spinal cord ischemia
- Article/chapterEnglish1994
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New York, USA :Academic Press,1994
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LIBRIS-ID:oai:DiVA.org:oru-81001
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81001URI
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https://doi.org/10.1006/exnr.1994.1157DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We have used the laser-induced photochemical thrombosis model in adult rats to evaluate the significance of the non-N-methyl-D-aspartate (non-NMDA) subtype of glutamate receptors in situations of focal spinal cord ischemia. The animals were pretreated with the selective non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX) or, for comparison, the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5-10-imine (MK-801). Neurological function was quantified using evaluations of motor score and inclined plane. The MK-801-treated rats had higher motor scores during the 3-week observation period while NBQX-treated rats only performed significantly better at 1 week. Both treatments caused significantly better performance in the inclined plane test. NBQX and MK-801 reduced the volume of necrosis by approximately 47% at 3 weeks postlesion. We conclude that blockade of both NMDA and non-NMDA subtypes of glutamate receptors reduces ischemic necrosis, possibly by preventing excessive stimulation of these receptors by released excitatory amino acids in the lesion area.
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Seiger, A.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
(author)
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Holmberg, L.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
(author)
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Sundström, E.Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
(author)
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Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Hudding University Hospital, Huddinge, Sweden
(creator_code:org_t)
Related titles
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In:Experimental NeurologyNew York, USA : Academic Press129:1, s. 163-1680014-48861090-2430
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