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Biomarkers for Trau...
Biomarkers for Traumatic Brain Injury : Data Standards and Statistical Considerations
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- Huie, J. Russell (author)
- Brain and Spinal Injury Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
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- Mondello, Stefania (author)
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
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- Lindsell, Christopher J. (author)
- Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
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- Antiga, Luca (author)
- Orobix Srl, Bergamo, Italy
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- Yuh, Esther L. (author)
- Brain and Spinal Injury Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA
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- Zanier, Elisa R. (author)
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy
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- Masson, Serge (author)
- Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy
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- Rosario, Bedda L. (author)
- Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
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- Ferguson, Adam R. (author)
- Brain and Spinal Injury Center, Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA; San Francisco Veterans Affairs Medical Center (SFVAMC), San Francisco, California, USA
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- Brorsson, Camilla (author)
- Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Mary Ann Liebert, 2021
- 2021
- English.
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In: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 38:18, s. 2514-2529
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Biomarkers
- data sharing
- traumatic brain injury
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Huie, J. Russell
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Mondello, Stefan ...
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Lindsell, Christ ...
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Antiga, Luca
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Yuh, Esther L.
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Zanier, Elisa R.
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Masson, Serge
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Rosario, Bedda L ...
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Ferguson, Adam R ...
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Brorsson, Camill ...
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Oresic, Matej, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomedical Labor ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
- Articles in the publication
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Journal of Neuro ...
- By the university
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Örebro University
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Umeå University
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Karolinska Institutet