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High risk of non-al...
High risk of non-alcoholic liver disease mortality in patients with chronic hepatitis C with illicit substance use disorder
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- Kåberg, Martin (author)
- Karolinska Institutet
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- Larsson, Simon B. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Jerkeman, Anna (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Nystedt, Anders (author)
- Department of Translational Medicine, Section of Infectious Disease, Malmö, Lund University, Malmö, Sweden,Norrbotten County Council
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- Duberg, Ann-Sofi, Docent, 1957- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases
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- Kövamees, Jan (author)
- AbbVie AB, Stockholm, Sweden
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- Ydreborg, Magdalena, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Aleman, Soo (author)
- Karolinska Institutet
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- Büsch, Katharina (author)
- AbbVie AB, Stockholm, Sweden; Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
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- Alanko Blomé, Marianne (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Region Skåne
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- Weiland, Ola (author)
- Karolinska Institutet
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- Söderholm, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-05-01
- 2020
- English.
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In: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:5, s. 574-580
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Abstract
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- Aims: Hepatitis C virus (HCV) is a slowly progressive disease, often transmitted among people who inject drugs (PWID). Mortality in PWID is high, with an overrepresentation of drug-related causes. This study investigated the risk of death in patients with chronic hepatitis C virus (HCV) infection with or without illicit substance use disorder (ISUD).Methods: Patients with HCV were identified using the Swedish National Patient Registry according to the International Classification of Diseases-10 (ICD-10) code B18.2, with ≤5 matched comparators from the general population. Patients with ≥2 physician visits with ICD-10 codes F11, F12, F14, F15, F16, or F19 were considered to have ISUD. The underlying cause of death was analyzed for alcoholic liver disease, non-alcoholic liver disease, liver cancer, drug-related and external causes, non-liver cancers, or other causes. Mortality risks were assessed using the standardized mortality ratio (SMR) with 95% CIs and Cox regression analyses for cause-specific hazard ratios.Results: In total, 38,186 patients with HCV were included, with 31% meeting the ISUD definition. Non-alcoholic liver disease SMRs in patients with and without ISUD were 123.2 (95% CI, 103.7-145.2) and 69.4 (95% CI, 63.8-75.3), respectively. The significant independent factors associated with non-alcoholic liver disease mortality were older age, being unmarried, male sex, and having ISUD.Conclusions: The relative risks for non-alcoholic liver disease mortality were elevated for patients with ISUD. Having ISUD was a significant independent factor for non-alcoholic liver disease. Thus, patients with HCV with ISUD should be given HCV treatment to reduce the risk for liver disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Hepatitis C
- chronic
- liver disease
- mortality
- substance abuse
- chronic
- Hepatitis C
- liver disease
- mortality
- substance abuse
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kåberg, Martin
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Larsson, Simon B ...
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Jerkeman, Anna
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Nystedt, Anders
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Duberg, Ann-Sofi ...
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Kövamees, Jan
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show more...
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Ydreborg, Magdal ...
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Aleman, Soo
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Büsch, Katharina
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Alanko Blomé, Ma ...
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Weiland, Ola
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Söderholm, Jonas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Scandinavian Jou ...
- By the university
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Örebro University
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Lund University
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Karolinska Institutet
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University of Gothenburg