Search: onr:"swepub:oai:DiVA.org:oru-81776" > Distribution and ch...
Fältnamn | Indikatorer | Metadata |
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000 | 04633naa a2200421 4500 | |
001 | oai:DiVA.org:oru-81776 | |
003 | SwePub | |
008 | 200511s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-817762 URI |
024 | 7 | a https://doi.org/10.1371/journal.pone.02325192 DOI |
040 | a (SwePub)oru | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hadgu, Endaleu Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut |
245 | 1 0 | a Distribution and characteristics of androgen receptor (AR) in breast cancer among women in Addis Ababa, Ethiopia :b A cross sectional study |
264 | c 2020-05-06 | |
264 | 1 | b Public Library Science,c 2020 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies:Addis Ababa University, School of Graduate Studies, thematic research group "clinico-epidemiological characterization of breast cancer in Ethiopia" Armauer Hansen Research Institute (AHRI) AHRI from Swedish International Developmental Agency (SIDA), Sweden | |
520 | a Evaluation of the role of androgen receptor (AR) in the biology of breast cancer is an emerging area of research. There are compelling evidences that AR expression may be used to further refine breast cancer molecular subtyping with prognostic and therapeutic implications. Many studies indicated co-expression of AR with the hormonal receptors in breast cancer has a favorable prognosis. AR is also investigated by many researchers as a potential therapeutic target in treatment of breast cancer. Studies on the frequency and distribution of AR in breast cancer among Africans is barely available. Given the heightened interest to understand its role in breast cancer, we determined AR expression and assessed its association with clinicopathological parameters among Ethiopian women. In this study, 112 newly diagnosed patient with invasive breast cancer at Tikur Anbessa Specialized Hospital were enrolled. Immunohistochemical assessment of AR, ER, PR, Ki67 and HER2 were performed using tissue microarrays (TMA) constructed from their primary tumor block. Out of the 112 participants, 91 (81%) were positive for AR expression and the remaining 21 participants (19%) were negative for AR expression. Expression of AR in ER+, HER2+ and TNBC cases were 93%, 83% and 48% respectively. Our study reveals AR is expressed in a significant number of breast cancers patients and this may indicate that breast cancers cases in Ethiopia have favorable prognosis and could benefit from progresses in AR targeted treatments. Since AR expression has important consequences on the prognosis and treatment of breast cancer, further studies with an increased number of participants is necessary to confirm our reports. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Seifu, Danielu Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut |
700 | 1 | a Tigneh, Wondemagegnhuu Department of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut |
700 | 1 | a Bokretsion, Yonasu Department of Pathology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut |
700 | 1 | a Bekele, Abebeu Department of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 aut |
700 | 1 | a Abebe, Markosu Armauer Hansen research Institute (AHRI), Addis Ababa, Ethiopia4 aut |
700 | 1 | a Sollie, Thomasu School of Medical Sciences, Örebro University, Örebro, Sweden4 aut |
700 | 1 | a Karlsson, Christina,d 1968-u Örebro universitet,Institutionen för hälsovetenskaper4 aut0 (Swepub:oru)ckn |
700 | 1 | a Karlsson, Mats G.,d 1960-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)mskn |
710 | 2 | a Department of Biochemistry, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopiab Department of Oncology, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia4 org |
773 | 0 | t PLOS ONEd : Public Library Scienceg 15:5q 15:5x 1932-6203 |
856 | 4 | u https://doi.org/10.1371/journal.pone.0232519y Fulltext |
856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0232519&type=printable |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-81776 |
856 | 4 8 | u https://doi.org/10.1371/journal.pone.0232519 |
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