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Decrease in primary...
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Kalman, Thordis DisaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US
(author)
Decrease in primary but not in secondary abdominal surgery for Crohn's disease : nationwide cohort study, 1990-2014
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-05-26
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John Wiley & Sons,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-82526
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-82526URI
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https://doi.org/10.1002/bjs.11659DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143767539URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166793URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:Johnson & Johnson USAJanssen Biotech IncTakeda Pharmaceutical Company LtdMSD Östergötland County
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Funding Agencies|Swedish Medical Society; Karolinska Institutet FoundationsKarolinska Institutet; Stockholm County CouncilStockholm County Council; Karolinska InstitutetKarolinska Institutet; JanssenJohnson & Johnson USAJanssen Biotech Inc; TakedaTakeda Pharmaceutical Company Ltd; MSD; Ostergotland County
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BACKGROUND: Treatment of patients with Crohn's disease has evolved in recent decades, with increasing use of immunomodulatory medication since 1990 and biologicals since 1998. In parallel, there has been increased use of active disease monitoring. To what extent these changes have influenced the incidence of primary and repeat surgical resection remains debated.METHODS: In this nationwide cohort study, incident patients of all ages with Crohn's disease, identified in Swedish National Patient Registry between 1990 and 2014, were divided into five calendar periods of diagnosis: 1990-1995 and 1996-2000 with use of inpatient registries, 2001, and 2002-2008 and 2009-2014 with use of inpatient and outpatient registries. The cumulative incidence of first and repeat abdominal surgery (except closure of stomas), by category of surgical procedure, was estimated using the Kaplan-Meier method.RESULTS: Among 21 273 patients with Crohn's disease, the cumulative incidence of first abdominal surgery within 5 years of Crohn's disease diagnosis decreased continuously from 54·8 per cent in 1990-1995 to 40·4 per cent in 1996-2000 (P < 0·001), and again from 19·8 per cent in 2002-2008 to 17·3 per cent in 2009-2014 (P < 0·001). Repeat 5-year surgery rates decreased from 18·9 per cent in 1990-1995 to 16·0 per cent in 1996-2000 (P = 0·009). After 2000, no further significant decreases were observed.CONCLUSION: The 5-year rate of surgical intervention for Crohn's disease has decreased significantly, but the rate of repeat surgery has remained stable despite the introduction of biological therapy.
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Everhov, Å. H.Karolinska Institutet,Soder Sjukhuset, Sweden; Karolinska Inst, Sweden
(author)
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Nordenvall, C.Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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Sachs, M. C.Karolinska Institutet,Karolinska Inst, Sweden
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Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Orebro Univ, Sweden(Swepub:oru)jshn
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Ekbom, A.Karolinska Institutet,Karolinska Inst, Sweden
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Ludvigsson, Jonas F.,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA(Swepub:oru)jsln
(author)
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Myrelid, PärLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)parmy24
(author)
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Olén, OKarolinska Institutet,Soder Sjukhuset, Sweden; Karolinska Inst, Sweden; Sachs Children and Youth Hosp, Sweden
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Ludvigsson, JEKarolinska Institutet,Karolinska Inst, Sweden; Orebro Univ, Sweden; Univ Nottingham, England; Columbia Univ, NY USA
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Linköpings universitetAvdelningen för kirurgi, ortopedi och onkologi
(creator_code:org_t)
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In:British Journal of Surgery: John Wiley & Sons107:11, s. 1529-15380007-13231365-2168
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Everhov, Å. H.
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Nordenvall, C.
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Ekbom, A.
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