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PDYN, a gene implic...
PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain
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- Henriksson, Richard (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Bäckman, Cristina M (author)
- Cellular Neurobiology Research Branch, Baltimore, USA
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- Harvey, Brandon K (author)
- Molecular Neuropsychiatry Research Branch, Baltimore, USA
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- Kadyrova, Helena (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Bazov, Igor, 1973- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Shippenberg, Toni S (author)
- Integrative Neuroscience Research Branch, Baltimore, USA
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- Bakalkin, Georgy (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- English.
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In: Biochimica et Biophysica Acta. - : Elsevier. - 0006-3002 .- 1878-2434. ; 1839:11, s. 1226-1232
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- The dynorphin κ-opioid receptor system is implicated in mental health and brain/mental disorders. However, despite accumulating evidence that PDYN and/or dynorphin peptide expression is altered in the brain of individuals with brain/mental disorders, little is known about transcriptional control of PDYN in humans. In the present study, we show that PDYN is targeted by the transcription factor REST in human neuroblastoma SH-SY5Y cells and that that interfering with REST activity increases PDYN expression in these cells. We also show that REST binding to PDYN is reduced in the adult human brain compared to SH-SY5Y cells, which coincides with higher PDYN expression. This may be related to MIR-9 mediated down-regulation of REST as suggested by a strong inverse correlation between REST and MIR-9 expression. Our results suggest that REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
Keyword
- MIR-9
- NRSF
- PDYN
- Prefrontal cortex
- REST
- SH-SY5Y cell
Publication and Content Type
- ref (subject category)
- art (subject category)
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