PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

Henriksson, Richard (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Bäckman, Cristina M (author): Cellular Neurobiology Research Branch, Baltimore, USA

Harvey, Brandon K (author): Molecular Neuropsychiatry Research Branch, Baltimore, USA

Kadyrova, Helena (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Bazov, Igor, 1973- (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

Shippenberg, Toni S (author): Integrative Neuroscience Research Branch, Baltimore, USA

Bakalkin, Georgy (author): Uppsala universitet,Institutionen för farmaceutisk biovetenskap

(creator_code:org_t)

Elsevier, 2014
2014
English.
In: Biochimica et Biophysica Acta. - : Elsevier. - 0006-3002 .- 1878-2434. ; 1839:11, s. 1226-1232

Related links:: https://www.ncbi.nlm...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Abstract Subject headings

The dynorphin κ-opioid receptor system is implicated in mental health and brain/mental disorders. However, despite accumulating evidence that PDYN and/or dynorphin peptide expression is altered in the brain of individuals with brain/mental disorders, little is known about transcriptional control of PDYN in humans. In the present study, we show that PDYN is targeted by the transcription factor REST in human neuroblastoma SH-SY5Y cells and that that interfering with REST activity increases PDYN expression in these cells. We also show that REST binding to PDYN is reduced in the adult human brain compared to SH-SY5Y cells, which coincides with higher PDYN expression. This may be related to MIR-9 mediated down-regulation of REST as suggested by a strong inverse correlation between REST and MIR-9 expression. Our results suggest that REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.

By the author/editor: Henriksson, Rich ...; Bäckman, Cristin ...; Harvey, Brandon ...; Kadyrova, Helena; Bazov, Igor, 197 ...; Shippenberg, Ton ...; show more...; Bakalkin, Georgy; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Medical Bioscien ...

By the university: Örebro University; Uppsala University; Karolinska Institutet

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.