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Erythropoietin seru...
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Lundgren, Pia,1967-Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
(author)
Erythropoietin serum levels, versus anaemia as risk factors for severe retinopathy of prematurity
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2018-09-18
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Nature Publishing Group,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-83346
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-83346URI
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https://doi.org/10.1038/s41390-018-0186-6DOI
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https://gup.ub.gu.se/publication/274600URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Preterm infants with anaemia are treated with recombinant human erythropoietin (rhEPO). It is debated whether rhEPO treatment is a risk factor for retinopathy of prematurity (ROP). We evaluated longitudinal EPO and haemoglobin levels, blood transfusions and neonatal morbidities as risk factors for severe ROP.Method: This prospective study included 78 Swedish infants, born <28 weeks gestational age (GA), screened for ROP. We tested serum EPO levels on postnatal days 1, 7, 14 and 28 and at postmenstrual ages 32, 36 and 40 weeks. Haemoglobin levels and blood transfusions were recorded during postnatal weeks 1-4. Anaemia was defined as haemoglobin ≤110 g/L.Results: During postnatal week 1, infants with severe ROP requiring treatment (28%) more frequently developed anaemia (42.9% versus 8.0%, P = 0.003) and had higher mean EPO levels (postnatal day 7: 14.2 versus 10.8 mIU/mL, P = 0.003) compared to infants with no or less severe ROP not requiring treatment. In multivariable analyses, GA and anaemia during week 1 remained significant risk factors, but elevated EPO level postnatal day 7 was no longer significant.Conclusions: Among infants born <28 weeks GA, anaemia during week 1 was a significant risk factor for severe ROP requiring treatment but not elevated EPO levels.
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Hellgren, Gunnel,1961Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xhegun
(author)
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Pivodic, AldinaStatistiska konsultgruppen, Gothenburg, Sweden
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Sävman, Karin,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xsavka
(author)
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Smith, Lois E. H.The Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA
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Hellström, Ann,1959Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xheann
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
Related titles
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In:Pediatric Research: Nature Publishing Group86:2, s. 276-2820031-39981530-0447
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