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Regulatory decision...
Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology
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- Vandenberg, Laura N. (author)
- Tufts University, Medford, USA
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- Colborn, Theo (author)
- The Endocrine Disruption Exchange, Paonia, USA
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- Hayes, Tyrone B. (author)
- University of California, Berkeley, USA
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- Heindel, Jerrold J. (author)
- National Institute of Environmental Health Sciences, Research Triangle Park, USA
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- Jacobs, David R., Jr (author)
- University of Minnesota, Minneapolis, USA
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- Lee, Duk-Hee (author)
- Kyungpook National University, Daegu, South Korea
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- Myers, John Peterson (author)
- Environmental Health Sciences, Charlottesville, USA
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- Shioda, Toshi (author)
- Massachusetts General Hospital, Center for Cancer Research, Charlestown, USA
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- Soto, Ana M. (author)
- Tufts University School of Medicine, Boston, USA
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- vom Saal, Frederick S. (author)
- University of Missouri-Columbia, Columbia, USA
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- Welshons, Wade V. (author)
- University of Missouri-Columbia, Columbia, MO, United States
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- Zoeller, R. Thomas, 1952- (author)
- Department of Biology, University of Massachusetts, Amherst, USA
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- English.
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In: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 38, s. 1-15
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- For years, scientists from various disciplines have studied the effects of endocrine disrupting chemicals (EDCs) on the health and wellbeing of humans and wildlife. Some studies have specifically focused on the effects of low doses, i.e. those in the range that are thought to be safe for humans and/or animals. Others have focused on the existence of non-monotonic dose-response curves. These concepts challenge the way that chemical risk assessment is performed for EDCs. Continued discussions have clarified exactly what controversies and challenges remain. We address several of these issues, including why the study and regulation of EDCs should incorporate endocrine principles; what level of consensus there is for low dose effects; challenges to our understanding of non-monotonicity; and whether EDCs have been demonstrated to produce adverse effects. This discussion should result in a better understanding of these issues, and allow for additional dialog on their impact on risk assessment.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Weight of evidence
- Organizational
- Adaptive effect
- Hormesis
- Human exposure
- Epidemiology
- Flare
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
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- By the author/editor
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Vandenberg, Laur ...
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Colborn, Theo
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Hayes, Tyrone B.
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Heindel, Jerrold ...
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Jacobs, David R. ...
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Lee, Duk-Hee
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show more...
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Myers, John Pete ...
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Shioda, Toshi
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Soto, Ana M.
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vom Saal, Freder ...
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Welshons, Wade V ...
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Zoeller, R. Thom ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Reproductive Tox ...
- By the university
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Örebro University