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Peer-reviewed and u...
Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals
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- Trasande, Leonardo (author)
- New York University School of Medicine, New York, USA; NYU Wagner School of Public Service, New York, USA; NYU Steinhardt School of Culture, Education and Human Development, New York, USA; NYU Global Institute of Public Health, New York, USA
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- Vandenberg, Laura N. (author)
- Department of Environmental Health Sciences, University of Massachusetts, Amherst, USA
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- Bourguignon, Jean-Pierre (author)
- University of Liège, Liège, Belgium
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- Myers, John Peterson (author)
- Environmental Health Sciences, Charlottesville, USA
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- Slama, Remy (author)
- CNRS, INSERM, Grenoble, France; University Grenoble Alpes, Grenoble, France
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- Vom Saal, Frederick (author)
- Division of Biological Sciences, University of Missouri-Columbia, Columbia, USA
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- Zoeller, R. Thomas, 1952- (author)
- Department of Biology, University of Massachusetts, Amherst, USA
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(creator_code:org_t)
- 2016-07-13
- 2016
- English.
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In: Journal of Epidemiology and Community Health. - : BMJ Publishing Group Ltd. - 0143-005X .- 1470-2738. ; 70:11, s. 1051-1056
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Evidence increasingly confirms that synthetic chemicals disrupt the endocrine system and contribute to disease and disability across the lifespan. Despite a United Nations Environment Programme/WHO report affirmed by over 100 countries at the Fourth International Conference on Chemicals Management, 'manufactured doubt' continues to be cast as a cloud over rigorous, peer-reviewed and independently funded scientific data. This study describes the sources of doubt and their social costs, and suggested courses of action by policymakers to prevent disease and disability. The problem is largely based on the available data, which are all too limited. Rigorous testing programmes should not simply focus on oestrogen, androgen and thyroid. Tests should have proper statistical power. 'Good laboratory practice' (GLP) hardly represents a proper or even gold standard for laboratory studies of endocrine disruption. Studies should be evaluated with regard to the contamination of negative controls, responsiveness to positive controls and dissection techniques. Flaws in many GLP studies have been identified, yet regulatory agencies rely on these flawed studies. Peer-reviewed and unbiased research, rather than 'sound science', should be used to evaluate endocrine-disrupting chemicals.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- ENDOCRINOLOGY
- ENVIRONMENTAL HEALTH
- Environmental epidemiology
- TOXICOLOGY
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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