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Infections in patie...
Infections in patients with multiple sclerosis : A national cohort study in Sweden
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- Castelo-Branco, Anna (author)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
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- Chiesa, Flaminia (author)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
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- Conte, Simona (author)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
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- Bengtsson, Camilla (author)
- Real-world Insights, IQVIA Nordics, Solna, Sweden
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- Lee, Sally (author)
- Celgene Corporation, 86 Morris Avenue, Summit, United States
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- Minton, Neil (author)
- Celgene Corporation, Summit, United States
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- Niemcryk, Steve (author)
- Celgene Corporation, Summit, United States
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- Lindholm, Anders (author)
- Celgene Corporation, Summit, United States
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- Rosenlund, Mats (author)
- Karolinska Institutet
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- Piehl, Fredrik (author)
- Karolinska Institutet
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- Montgomery, Scott, 1961- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro University Hospital, Örebro, Sweden; Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 45
- Related links:
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https://doi.org/10.1...
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http://www.msard-jou...
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Abstract
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- BACKGROUND: Multiple sclerosis (MS) patients have an increased risk of infections, but few population-based studies have reported infections occurring in MS in the years immediately after diagnosis.OBJECTIVE: To explore incident infections in MS, stratified by age and sex.METHODS: In a Swedish population-based cohort study 6602 incident MS patients (aged ≥18 years), matched at diagnosis with 61,828 matched MS-free individuals were identified between 1st January 2008 and 31st December 2016, using national registers. Incidence rates (IR) and incidence rate ratios (IRR) with 95% CI were calculated for each outcome.RESULTS: The IRRs were 2.54 (95% CI 2.28-2.83) for first serious infection and 1.61 (1.52-1.71) for first non-serious infection. Compared with MS-free individuals, MS patients had higher IRs for skin, respiratory/throat infections, pneumonia/influenza, bacterial, viral, and fungal infections, with the highest IRR observed for urinary tract/kidney infections (2.44; 2.24-2.66). The cumulative incidence for most of these infections was higher among MS patients than MS-free individuals, both 0 to <5 and 5 to <9 years after index date.CONCLUSION: The burden of infections around the time of MS diagnosis and subsequent infection risk, underscore the need for careful considerations regarding the risk-benefit across different disease-modifying therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Cohort study
- Comorbidities
- Health registers
- Incidence
- Infections
- Multiple sclerosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Castelo-Branco, ...
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Chiesa, Flaminia
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Conte, Simona
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Bengtsson, Camil ...
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Lee, Sally
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Minton, Neil
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show more...
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Niemcryk, Steve
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Lindholm, Anders
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Rosenlund, Mats
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Piehl, Fredrik
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Montgomery, Scot ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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Multiple Scleros ...
- By the university
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Örebro University
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Karolinska Institutet