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Sökning: onr:"swepub:oai:DiVA.org:oru-85162" > Enlarged perivascul...

  • Granberg, TobiasKarolinska Institutet (författare)

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging : a systematic review and meta-analysis

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-06-13
  • Springer,2020
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-85162
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-85162URI
  • https://doi.org/10.1007/s00415-020-09971-5DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143900258URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Funding Agency:Swiss National Science Foundation (SNSF)
  • BACKGROUND: Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces. EPVS have been linked to small vessel disease. Some studies have also indicated an association of EPVS to neuroinflammation and/or neurodegeneration. However, there is conflicting evidence with regards to their potential as a clinically relevant imaging biomarker in multiple sclerosis (MS).METHODS: To perform a systematic review and meta-analysis of EPVS as visualized by MRI in MS. Nine out of 299 original studies addressing EPVS in humans using MRI were eligible for the systematic review and meta-analysis including a total of 457 MS patients and 352 control subjects.RESULTS: In MS, EPVS have been associated with cognitive decline, contrast-enhancing MRI lesions, and brain atrophy. Yet, these associations were not consistent between studies. The meta-analysis revealed that MS patients have greater EPVS prevalence (odds ratio = 4.61, 95% CI = [1.84; 11.60], p = 0.001) as well as higher EPVS counts (standardized mean difference [SMD] = 0.46, 95% CI = [0.26; 0.67], p < 0.001) and larger volumes (SMD = 0.88, 95% CI = [0.19; 1.56], p = 0.01) compared to controls.CONCLUSIONS: Available literature suggests a higher EPVS burden in MS patients compared to controls. The association of EPVS to neuroinflammatory or -degenerative pathology in MS remains inconsistent. Thus, there is currently insufficient evidence supporting EPVS as diagnostic and/or prognostic marker in MS. In order to benefit future comparisons of studies, we propose recommendations on EPVS assessment standardization in MS. PROSPERO No: CRD42019133946.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Moridi, ThomasKarolinska Institutet (författare)
  • Brand, Judith,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics(Swepub:oru)jhbd (författare)
  • Neumann, SusanneDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (författare)
  • Hlavica, MartinDepartment of Neurosurgery, Inselspital, University of Bern, Bern, Switzerland (författare)
  • Piehl, FredrikKarolinska Institutet (författare)
  • Ineichen, Benjamin V.Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden (författare)
  • Karolinska InstitutetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Neurology: Springer267:11, s. 3199-32120340-53541432-1459

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