Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial

Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly : A Randomised Placebo Controlled Parallel Clinical Trial

Ganda Mall, John Peter, 1988- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Fac Med & Hlth, Sch Med Sci, Sodra Grey Rosengatan 32, S-70362 Orebro, Sweden.

Fart, Frida, 1992- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden

Sabet, Julia A., 1986- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden

Lindqvist, Carl Mårten, 1979- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden

Nestestog, Ragnhild (author): Genetic Analysis AS, Oslo, Norway,Genet Anal AS, Norway

Hegge, Finn Terje (author): Genetic Analysis AS, Oslo, Norway,Genet Anal AS, Norway

Keita, Åsa (author): Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten

Brummer, Robert Jan, 1957- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden

Schoultz, Ida, 1979- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden

(creator_code:org_t)

Related links:: https://doi.org/10.3...; show more...; https://www.mdpi.com...; https://liu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.3...; https://urn.kb.se/re...; show less...

Abstract Subject headings

The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat beta-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (>= 65 years,n= 49) was randomised to a daily supplementation (12g/day) of oat beta-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo.

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

By the author/editor: Ganda Mall, John ...; Fart, Frida, 199 ...; Sabet, Julia A., ...; Lindqvist, Carl ...; Nestestog, Ragnh ...; Hegge, Finn Terj ...; show more...; Keita, Åsa; Brummer, Robert ...; Schoultz, Ida, 1 ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Other Clinical M ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.