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Early-life exposure...
Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease
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- Sinisalu, Lisanna, 1993- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Sen, Partho (author)
- Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Virtanen, Suvi M. (author)
- Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
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- Hyöty, Heikki (author)
- Faculty of Medicine Health Technology, Tampere University, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
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- Ilonen, Jorma (author)
- Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland
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- Toppari, Jorma (author)
- Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, And Centre for Population Health Research, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland
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- Veijola, Riitta (author)
- Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
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- Knip, Mikael (author)
- Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland
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- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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(creator_code:org_t)
- Academic Press, 2020
- 2020
- English.
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In: Environmental Research. - : Academic Press. - 0013-9351 .- 1096-0953. ; 188
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https://doi.org/10.1...
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Abstract
Subject headings
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- Celiac disease (CD) is a systemic immune-mediated disorder with increased frequency in the developed countries over the last decades implicating the potential causal role of various environmental triggers in addition to gluten. Herein, we apply determination of perfluorinated alkyl substances (PFAS) and combine the results with the determination of bile acids (BAs) and molecular lipids, with the aim to elucidate the impact of prenatal exposure on risk of progression to CD in a prospective series of children prior the first exposure to gluten (at birth and at 3 months of age). Here we analyzed PFAS, BAs and lipidomic profiles in 66 plasma samples at birth and at 3 months of age in the Type 1 Diabetes Prediction and Prevention (DIPP) study (n = 17 progressors to CD, n = 16 healthy controls, HCs). Plasma PFAS levels showed a significant inverse association with the age of CD diagnosis in infants who later progressed to the disease. Associations between BAs and triacylglycerols (TGs) showed different patterns already at birth in CD progressors, indicative of different absorption of lipids in these infants. In conclusion, PFAS exposure may modulate lipid and BA metabolism, and the impact is different in the infants who develop CD later in life, in comparison to HCs. The results indicate more efficient uptake of PFAS in such infants. Higher PFAS exposure during prenatal and early life may accelerate the progression to CD in the genetically predisposed children.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Bile acids
- Celiac disease
- Exposome
- Lipidomics
- PFAS
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sinisalu, Lisann ...
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Sen, Partho
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Salihovic, Samir ...
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Virtanen, Suvi M ...
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Hyöty, Heikki
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Ilonen, Jorma
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Toppari, Jorma
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Veijola, Riitta
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Oresic, Matej, 1 ...
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Knip, Mikael
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Hyötyläinen, Tuu ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environmental Re ...
- By the university
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Örebro University
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Karolinska Institutet