Relapse risk after in-ward electroconvulsive therapy for acute polymorphic psychotic disorder

Kalling, Styrbjörn (author): Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Uppsala Univ, Sweden

Brus, Ole, 1982- (author): Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics,Orebro Univ, Sweden

Landén, Mikael, 1966 (author): Gothenburg University,Göteborgs universitet,Karolinska Institutet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry

Nordanskog, Pia, 1971- (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping

Nordenskjöld, Axel, 1977- (author): Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Centre,Orebro Univ, Sweden

(creator_code:org_t)

2020-10-23
2021
English.
In: Nordic Journal of Psychiatry. - : Taylor & Francis. - 0803-9488 .- 1502-4725. ; 75:3, s. 201-206

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Abstract Subject headings

PURPOSE: Acute polymorphic psychotic disorder (APPD) without symptoms of schizophrenia is a serious psychiatric condition. APPD can be effectively treated with electroconvulsive therapy (ECT), but little is known about relapse prevention after ECT for APPD.MATERIALS AND METHODS: This was a retrospective register-based study conducted with 97 patients with APPD (ICD-10 diagnosis F23.0). We estimated the rates of readmission and suicide, and the prognostic factors of these outcomes after ECT. We combined data from several national Swedish registers and used Cox's regression analysis to identify demographic factors, disease characteristics, and relapse preventive treatments that predicted time to readmission or suicide (relapse). Data registered between 2011 and 2016 were used in the study.RESULTS: Twenty percent of cases relapsed within a year. Thereafter, relapse rate was low. Two cases died during follow-up, whereof one by suicide. Anxiolytic treatment, lamotrigine treatment, and having more than four previous psychiatric hospital admissions were associated with shorter time to relapse. The most robust of these associations was between anxiolytics and relapse risk.CONCLUSIONS: The first year after discharge from APPD is the period associated with the highest risk of relapse. Having many previous admissions was associated to relapse risk after ECT for APPD. The associations between anxiolytics, lamotrigine, and relapse are uncertain and might be influenced by indication bias.

By the author/editor: Kalling, Styrbjö ...; Brus, Ole, 1982-; Landén, Mikael, ...; Lundberg, Johan; Nordanskog, Pia, ...; Nordenskjöld, Ax ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

By the university: Örebro University; Uppsala University; Linköping University; Karolinska Institutet; University of Gothenburg

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