Search: onr:"swepub:oai:DiVA.org:oru-87655" >
Effects of a Lacto-...
Effects of a Lacto-Ovo-Vegetarian Diet on the Plasma Lipidome and Its Association with Atherosclerotic Burden in Patients with Coronary Artery Disease-A Randomized, Open-Label, Cross-over Study
-
- Djekic, Demir, 1989- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology,Örebro läns landsting
-
- Shi, Lin, 1988 (author)
- School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China; Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology,Shaanxi Normal University
-
- Calais, Fredrik, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology,Örebro läns landsting
-
show more...
-
- Carlsson, Frida, 1983 (author)
- Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
-
- Landberg, Rikard (author)
- Umeå universitet,Kardiologi,Division of Food and Nutrition Science, Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden,Umeå University,Chalmers tekniska högskola,Chalmers University of Technology
-
- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro University
-
- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology,Örebro läns landsting
-
show less...
-
(creator_code:org_t)
- 2020-11-23
- 2020
- English.
-
In: Nutrients. - : MDPI. - 2072-6643. ; 12:11
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://www.mdpi.com...
-
https://umu.diva-por... (primary) (Raw object)
-
https://research.cha... (primary) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
https://research.cha...
-
show less...
Abstract
Subject headings
Close
- A vegetarian diet has been associated with a lower risk of coronary artery disease (CAD). Plasma triacylglycerols, ceramides, and phosphatidylcholines may improve prediction of recurrent coronary events. We sought to investigate effects of a lacto-ovo-vegetarian diet (VD) on plasma lipidome in CAD patients and simultaneously assess associations of plasma lipids with the extent of coronary atherosclerotic burden. We analyzed 214 plasma lipids within glycerolipid, sphingolipid, and sterol lipid classes using lipidomics from a randomized controlled, crossover trial comprising 31 CAD patients on standard medical therapy. Subjects completed a four-week intervention with VD and isocaloric meat diet (MD), separated by a four-week washout period. The VD increased levels of 11 triacylglycerols and lowered 7 triacylglycerols, 21 glycerophospholipids, cholesteryl ester (18:0), and ceramide (d18:1/16:0) compared with MD. VD increased triacylglycerols with long-chain polyunsaturated fatty acyls while decreased triacylglycerols with saturated fatty acyls, phosphatidylcholines, and sphingomyelins than MD. The Sullivan extent score (SES) exhibited on coronary angiograms were inversely associated with triacylglycerols with long-chain unsaturated fatty acyls. Phosphatidylcholines that were lower with VD were positively associated with SES and the total number of stenotic lesions. The VD favorably changed levels of several lipotoxic lipids that have previously been associated with increased risk of coronary events in CAD patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Coronary artery disease
- lipidomics
- randomized controlled trial
- vegetarian diet
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Nutrients
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Djekic, Demir, 1 ...
-
Shi, Lin, 1988
-
Calais, Fredrik, ...
-
Carlsson, Frida, ...
-
Landberg, Rikard
-
Hyötyläinen, Tuu ...
-
show more...
-
Fröbert, Ole, 19 ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Nutrients
- By the university
-
Örebro University
-
Umeå University
-
Chalmers University of Technology