Association Between Early Prescribed Opioid Initiation and Risk of Suicidal Behavior

Fine, Kimberly L.Department of Applied Health Science, School of Public Health, Indiana University, Bloomington (author)

Kimberly L. Fine, PhD was presenting the poster.
Prescription opioid use has been linked to increased risk of suicidal behavior in adults. However, little research exists examining the role of prescription opioid use on risk of suicidal behavior in children and adolescents. This population is at high risk for suicidal behavior, as suicide is the second leading cause of death for people ages 10 to 34. Using healthcare data from Swedish population registers, we aimed to characterize the extent to which exposure to opioids at a young age leads to an increased risk of new onset suicidal behavior, for those with no history of suicidal behavior. Compared to demographically matched non-recipients, young people who initiated prescription opioids had just under three times the rate of subsequent suicidal behavior (HR = 2.64, 95% CI, 2.47-2.81). Compared to their unexposed siblings, young people who initiated prescription opioids had roughly two times the rate of subsequent suicidal behavior (HR = 1.83, 95% CI, 1.67-2.01). Finally, compared to young people initiating prescription NSAIDs, young people who initiated prescription opioids had only 19% relatively greater rates of suicidal behavior (HR, 1.19, 95% CI, 1.11-1.27). These results suggest the association between prescription opioids and suicidal behavior may be driven by the underlying pain indication.

Rickert, Martin E.Department of Psychological and Brain Sciences, Indiana University, Bloomington (author)
O'Reilly, Lauren M.Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, USA (author)
Sujan, Ayesha C.Department of Psychological and Brain Sciences, Indiana University, Bloomington (author)
Boersma, Katja,professor,1973-Örebro universitet,Institutionen för juridik, psykologi och socialt arbete(Swepub:oru)kba (author)
Chang, ZhengDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
Franck, JohanDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
Lichtenstein, PaulDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)hiln (author)
D'Onofrio, Brian M.Department of Psychological and Brain Sciences, Indiana University, Bloomington; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)
Quinn, Patrick D.Department of Applied Health Science, School of Public Health, Indiana University, Bloomington (author)
Department of Applied Health Science, School of Public Health, Indiana University, BloomingtonDepartment of Psychological and Brain Sciences, Indiana University, Bloomington (creator_code:org_t)

By the author/editor: Fine, Kimberly L ...; Rickert, Martin ...; O'Reilly, Lauren ...; Sujan, Ayesha C.; Boersma, Katja, ...; Chang, Zheng; show more...; Franck, Johan; Lichtenstein, Pa ...; Larsson, Henrik, ...; D'Onofrio, Brian ...; Quinn, Patrick D ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Geriatrics

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