Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations

Lamichhane, SantoshTurku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland (author)

Linking Gut Microbiome and Lipid Metabolism : Moving beyond Associations

Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in health and disease have primarily focused on water-soluble polar metabolites, whilst non-polar microbial lipids have received less attention. The concept of microbiota-dependent lipid biotransformation is over a century old. However, only recently, several studies have shown how microbial lipids alter intestinal and circulating lipid concentrations in the host, thus impacting human lipid homeostasis. There is emerging evidence that gut microbial communities play a particularly significant role in the regulation of host cholesterol and sphingolipid homeostasis. Here, we review and discuss recent research focusing on microbe-host-lipid co-metabolism. We also discuss the interplay of human gut microbiota and molecular lipids entering host systemic circulation, and its role in health and disease.

Sen, Partho,1983-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland(Swepub:oru)posn (author)
Alves, Marina AmaralTurku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland (author)
Ribeiro, Henrique C.Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland (author)
Raunioniemi, PeppiTurku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland (author)
Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (author)
Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, Finland; Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan, China(Swepub:oru)moc (author)
Turku Bioscience Centre, University of Turku and Abo Akademi University, Turku, FinlandInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Lamichhane, Sant ...; Sen, Partho, 198 ...; Alves, Marina Am ...; Ribeiro, Henriqu ...; Raunioniemi, Pep ...; Hyötyläinen, Tuu ...; show more...; Oresic, Matej, 1 ...; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Bioinformatics a ...

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