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Interchangeability ...
Interchangeability of light and virtual microscopy for histopathological evaluation of prostate cancer
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- Zelic, Renata (author)
- Karolinska Institutet
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- Giunchi, Francesca (author)
- Department of Pathology, S-Orsola-Malpighi Hospital, Bologna, Italy
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- Lianas, Luca (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Mascia, Cecilia (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Zanetti, Gianluigi (author)
- Data-Intensive Computing Division, Center for Advanced Studies, Research and Development in Sardinia (CRS4), Pula, Italy
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- Andrén, Ove, 1963- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Urology
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- Fridfeldt, Jonna (author)
- Department of Urology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Carlsson, Jessica, 1984- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
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- Davidsson, Sabina, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Urology
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- Molinaro, Luca (author)
- Division of Pathology, A.O. Città Della Salute e Della Scienza Hospital, Turin, Italy
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- Vincent, Per Henrik (author)
- Karolinska Institutet
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- Richiardi, Lorenzo (author)
- Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, and CPO-Piemonte, Turin, Italy
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- Akre, Olof (author)
- Karolinska Institutet
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- Fiorentino, Michelangelo (author)
- Department of Pathology, Maggiore Hospital, University of Bologna, Bologna, Italy
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- Pettersson, Andreas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-02-05
- 2021
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
- Related links:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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Abstract
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- Virtual microscopy (VM) holds promise to reduce subjectivity as well as intra- and inter-observer variability for the histopathological evaluation of prostate cancer. We evaluated (i) the repeatability (intra-observer agreement) and reproducibility (inter-observer agreement) of the 2014 Gleason grading system and other selected features using standard light microscopy (LM) and an internally developed VM system, and (ii) the interchangeability of LM and VM. Two uro-pathologists reviewed 413 cores from 60 Swedish men diagnosed with non-metastatic prostate cancer 1998-2014. Reviewer 1 performed two reviews using both LM and VM. Reviewer 2 performed one review using both methods. The intra- and inter-observer agreement within and between LM and VM were assessed using Cohen's kappa and Bland and Altman's limits of agreement. We found good repeatability and reproducibility for both LM and VM, as well as interchangeability between LM and VM, for primary and secondary Gleason pattern, Gleason Grade Groups, poorly formed glands, cribriform pattern and comedonecrosis but not for the percentage of Gleason pattern 4. Our findings confirm the non-inferiority of VM compared to LM. The repeatability and reproducibility of percentage of Gleason pattern 4 was poor regardless of method used warranting further investigation and improvement before it is used in clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- ref (subject category)
- art (subject category)
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Zelic, Renata
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Giunchi, Frances ...
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Lianas, Luca
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Mascia, Cecilia
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Zanetti, Gianlui ...
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Andrén, Ove, 196 ...
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Fridfeldt, Jonna
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Carlsson, Jessic ...
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Davidsson, Sabin ...
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Molinaro, Luca
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Vincent, Per Hen ...
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Richiardi, Loren ...
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Akre, Olof
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Fiorentino, Mich ...
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Pettersson, Andr ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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Scientific Repor ...
- By the university
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Örebro University
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Karolinska Institutet