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Bridging animal and...
Bridging animal and clinical research during SARS-CoV-2 pandemic : A new-old challenge
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- Winkler, Martin S. (author)
- Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Göttingen, Germany
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- Skirecki, Tomasz (author)
- Laboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland
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- Brunkhorst, Frank M. (author)
- Dept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, Jena, Germany; Center for Clinical Studies, Jena University Hospital, Jena, Germany
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- Cajander, Sara, 1980- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases
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- Cavaillon, Jean-Marc (author)
- French National Research Agency (ANR), Paris, France
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- Ferrer, Ricard (author)
- Intensive Care Department and Shock, Organ Dysfunction and Resuscitation Research Group, Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain; Centro de Investigación Biomedica En Red-Enfermedades Respiratorias (CibeRes, CB06/06/0028), Instituto de salud Carlos III (ISCIII), Madrid, Spain
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- Flohé, Stefanie B. (author)
- Department of Trauma, Hand, and Reconstructive Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany
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- García-Salido, Alberto (author)
- Pediatric Critical Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
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- Giamarellos-Bourboulis, Evangelos J. (author)
- 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece
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- Girardis, Massimo (author)
- Department of Anesthesia and Intensive Care, University Hospital of Modena, Italy
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- Kox, Matthijs (author)
- Department of Intensive Care Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands
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- Lachmann, Gunnar (author)
- Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany
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- Martin-Loeches, Ignacio (author)
- Multidisciplinary Intensive Care Research Organization (MICRO), St. James's Hospital, James's St N, Ushers, Dublin, Ireland
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- Netea, Mihai G. (author)
- Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands
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- Spinetti, Thibaud (author)
- Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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- Schefold, Joerg C. (author)
- Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
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- Torres, Antoni (author)
- Pneumology Department, Respiratory Institute (ICR), Hospital Clinic of Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) - University of Barcelona (UB), Spain
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- Uhle, Florian (author)
- Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany
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- Venet, Fabienne (author)
- Hospices Civils de Lyon, Immunology Laboratory, Edouard Herriot Hospital, Lyon, France; EA 7426 "Pathophysiology of Injury-Induced Immunosuppression - PI3", Université Claude Bernard Lyon 1/bioMérieux/Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France
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- Weis, Sebastian (author)
- Dept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, Jena, Germany; Institute for Infectious Disease and Infection Control, Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, Jena, Germany
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- Scherag, André (author)
- Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital-Friedrich Schiller University, Jena, Germany
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- Rubio, Ignacio (author)
- Dept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Am Klinikum 1, Jena, Germany
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- Osuchowski, Marcin F. (author)
- Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
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In: EBioMedicine. - : Elsevier. - 2352-3964. ; 66
- Related links:
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https://doi.org/10.1...
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Abstract
Subject headings
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- Many milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Animal model
- COVID-19
- Clinical trial
- Pandemic
- Pre-clinical research
- Vaccine
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- By the author/editor
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Winkler, Martin ...
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Skirecki, Tomasz
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Brunkhorst, Fran ...
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Cajander, Sara, ...
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Cavaillon, Jean- ...
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Ferrer, Ricard
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Flohé, Stefanie ...
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García-Salido, A ...
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Giamarellos-Bour ...
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Girardis, Massim ...
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Kox, Matthijs
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Lachmann, Gunnar
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Martin-Loeches, ...
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Netea, Mihai G.
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Spinetti, Thibau ...
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Schefold, Joerg ...
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Torres, Antoni
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Uhle, Florian
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Venet, Fabienne
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Weis, Sebastian
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Scherag, André
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Rubio, Ignacio
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Osuchowski, Marc ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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EBioMedicine
- By the university
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Örebro University