Search: onr:"swepub:oai:DiVA.org:oru-90975" >
The Prognostic Role...
The Prognostic Role of LRIG Proteins in Endometrial Cancer
-
- Razumova, Zoia (author)
- Karolinska Institutet
-
- Oda, Husam (author)
- Umeå universitet,Patologi
-
- Govorov, Igor (author)
- Karolinska Institutet
-
show more...
-
- Lundin, Eva (author)
- Umeå universitet,Patologi
-
- Östensson, Ellinor (author)
- Karolinska Institutet
-
- Lindquist, David (author)
- Umeå universitet,Professionell utveckling
-
- Mints, Miriam, 1958- (author)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Division of Neonatology, Obstetrics and Gynecology, Department of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
show less...
-
(creator_code:org_t)
-
-
show more...
-
-
show less...
- ISSN 2072-6694
- 2021-03-17
- 2021
- English.
-
In: Cancers. - Stockholm : MDPI. - 2072-6694. ; 13:6
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://www.mdpi.com...
-
https://umu.diva-por... (primary) (Raw object)
-
http://hdl.handle.ne... (primary) (Object in context) (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
http://hdl.handle.ne...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Endometrial cancer (EC) is the most common gynecologic malignancy in Sweden and it has various prognostic factors. The LRIG family is a group of three integral surface proteins with a similar domain organization. The study aimed to explore LRIG family as prognostic factor proteins in EC. The initial study cohort included 100 women with EC who were treated at the Department of Women’s and Children’s Health, Karolinska University Hospital Solna, between 2007 and 2012. We assessed the associations between LRIG protein expression and type, grade, and stage of EC, as well as progression-free and overall survival. Immunohistochemistry results revealed that most women in the analytical sample had >50% LRIG1-, LRIG2- and LRIG3-positive cells. A statistically significant association was observed between having a high number of LRIG3-positive cells and superior overall survival (incidence rate ratio = 0.977; 95% confidence interval: 0.958–0.996, p = 0.019). Moreover, positive LRIG3 staining of the cell membrane was associated with reducing in the risk of death (hazard ratio = 0.23; 95% confidence interval: 0.09–0.57). Our results show that LRIG3 expression might be a prognostic factor in EC. The role of LRIG1 and LRIG2 expression remains to be further investigated.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- LRIG1
- LRIG2
- LRIG3
- endometrial cancer
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database