SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-91042"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-91042" > The brominated flam...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005546naa a2200541 4500
001oai:DiVA.org:oru-91042
003SwePub
008210414s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-182483
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-910422 URI
0247 a https://doi.org/10.1016/j.reprotox.2021.04.0022 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1824832 URI
040 a (SwePub)orud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bereketoglu, Ceyhunu Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden,Biology, The Life Science Center4 aut
2451 0a The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse
264 1b Elsevier,c 2021
338 a print2 rdacarrier
500 a Funding Agency:Örebro University  
520 a The brominated flame retardants (BFRs), 1,2-dibromo-4-(1,2 dibromoethyl)cyclohexane (TBECH) and 2,3-dibromopropyl-2,4,6-tribromophenyl ether (DPTE) bind to the androgen receptor (AR). In vitro bioassays have shown that TBECH is a potent androgen agonist while DPTE is a potent AR antagonist. Both TBECH and DPTE alter gene expression associated with AR regulation. However, it remains to be determined if TBECH and DPTE can affect the prostate. For this reason, we exposed CD1 mice to a 1:1 mixture of TBECH diastereomers α and β, a 1:1 mixture of γ and δ, and to DPTE, and tested their effects on prostate growth, histology and gene expression profiles. Castrated (C) mice were used to study the androgenic effects of TBECHαβ and TBECHγδ while the antagonistic effects of DPTE were studied in non-castrated (NC) mice. We observed that testosterone and TBECHγδ increased body and prostate weights while TBECHαβ affected neither of them; and that DPTE had no effect on body weight but reduced prostate weight drastically. Histomorphometric analysis of the prostate revealed epithelial and glandular alterations in the TBECHγδ group comparable to those in testosterone group while alterations in the TBECHαβ group were less pronounced. DPTE displayed androgen antagonist activity reminiscent of castration. The transcription profile of the prostate was altered by castration and exposure to testosterone and to TBECHγδ reversed several of these changes. Testosterone and TBECHγδ also regulated the expression of several androgen responsive genes implicated in prostate growth and cancer. While DPTE resulted in a drastic reduction in prostate weight, it only affected a small number of genes. The results indicate that TBECHγδ and DPTE are of high human health concern as they may contribute to changes in prostate growth, histology and function.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a DPTE
653 a TBECH
653 a androgenic
653 a anti-androgenic
653 a gene expression
653 a prostate
7001 a Modig, Carina,d 1963-u Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)cmg
7001 a Pradhan, Ajay,d 1983-u Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)aypn
7001 a Andersson, Patrik L.u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)paan0001
7001 a Stasinopoulou, Sotiriau Molecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece4 aut
7001 a Mitsiou, Dimitra J.u Molecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece4 aut
7001 a Alexis, Michael N.u Molecular Endocrinology Program, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece4 aut
7001 a Olsson, Per-Erik,d 1957-u Örebro universitet,Institutionen för naturvetenskap och teknik,Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)pkon
7102 a Biology, The Life Science Center, School of Science and Technology, Örebro University, Örebro, Swedenb Biology, The Life Science Center4 org
7730 t Reproductive Toxicologyd : Elsevierg 102, s. 43-55q 102<43-55x 0890-6238x 1873-1708
8564 u https://doi.org/10.1016/j.reprotox.2021.04.002y Fulltext
8564 u https://doi.org/10.1016/j.reprotox.2021.04.002
8564 u https://umu.diva-portal.org/smash/get/diva2:1546726/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91042
8564 8u https://doi.org/10.1016/j.reprotox.2021.04.002
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182483

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy