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Mortality After Isc...
Mortality After Ischemic Stroke in Patients with Alzheimer's Disease Dementia and Other Dementia Disorders
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- Zupanic, Eva (author)
- Karolinska Institute,University Medical Centre Ljubljana,University of Ljubljana
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- von Euler, Mia, 1967- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden,Örebro University Hospital
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- Winblad, Bengt (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Xu, Hong (author)
- Karolinska Institutet,Karolinska Institute
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- Secnik, Juraj (author)
- Karolinska Institutet,Karolinska Institute
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- Kramberger, Milica Gregoric (author)
- Karolinska Institute,University Medical Centre Ljubljana,University of Ljubljana
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- Religa, Dorota (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Norrving, Bo (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Stroke policy och kvalitetsregisterforskning,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Stroke policy and quality register research,Skåne University Hospital
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- Garcia-Ptacek, Sara (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- IOS Press, 2021
- 2021
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 81:3, s. 1253-1261
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Abstract
Subject headings
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- BACKGROUND: Stroke and dementia are interrelated diseases and risk for both increases with age. Even though stroke incidence and age-standardized death rates have decreased due to prevention of stroke risk factors, increased utilization of reperfusion therapies, and other changes in healthcare, the absolute numbers are increasing due to population growth and aging.OBJECTIVE: To analyze predictors of death after stroke in patients with dementia and investigate possible time and treatment trends.METHODS: A national longitudinal cohort study 2007-2017 using Swedish national registries. We compared 12,629 ischemic stroke events in patients with dementia with matched 57,954 stroke events in non-dementia controls in different aspects of patient care and mortality. Relationship between dementia status and dementia type (Alzheimer's disease and mixed dementia, vascular dementia, other dementias) and death was analyzed using Cox regressions.RESULTS: Differences in receiving intravenous thrombolysis between patients with and without dementia disappeared after the year 2015 (administered to 11.1% dementia versus 12.3% non-dementia patients, p = 0.117). One year after stroke, nearly 50% dementia and 30% non-dementia patients had died. After adjustment for demographics, mobility, nursing home placement, and comorbidity index, dementia was an independent predictor of death compared with non-dementia patients (HR 1.26 [1.23-1.29]).CONCLUSION: Dementia before ischemic stroke is an independent predictor of death. Over time, early and delayed mortality in patients with dementia remained increased, regardless of dementia type. Patients with≤80 years with prior Alzheimer's disease or mixed dementia had higher mortality rates after stroke compared to patients with prior vascular dementia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Alzheimer’s disease
- dementia
- ischemic stroke
- mixed dementia
- mortality
- vascular dementia
- Alzheimer's disease
- dementia
- ischemic stroke
- mixed dementia
- mortality
- vascular dementia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zupanic, Eva
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von Euler, Mia, ...
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Winblad, Bengt
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Xu, Hong
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Secnik, Juraj
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Kramberger, Mili ...
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show more...
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Religa, Dorota
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Norrving, Bo
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Garcia-Ptacek, S ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Örebro University
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Lund University
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Karolinska Institutet