Microscopic Colitis and Risk Of Cancer-AA Population-Based Cohort Study

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Bergman, DavidKarolinska Institutet (author)

Microscopic Colitis and Risk Of Cancer-AA Population-Based Cohort Study

Article/chapterEnglish2021

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2020-07-25
Oxford University Press,2021
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LIBRIS-ID:oai:DiVA.org:oru-91741
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-91741URI
https://doi.org/10.1093/ecco-jcc/jjaa156DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:146385182URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Background and Aims: The association between microscopic colitis [MC] and cancer risk is unclear. Large, population-based studies are lacking.Methods: We conducted a nationwide cohort study of 11 758 patients with incident MC [diagnosed 1990-2016 in Sweden], 50 828 matched reference individuals, and 11 614 siblings to MC patients. Data were obtained through Sweden's pathology departments and from the Swedish Cancer Register. Adjusted hazard ratios [aHRs] were calculated using Cox proportional hazards models.Results: At the end of follow-up [mean: 6.7 years], 1239 [10.5%] of MC patients had received a cancer diagnosis, compared with 4815 [9.5%] of reference individuals (aHR 1.08 [95% confidence interval1.02-1.16]). The risk of cancer was highest during the first year of follow up. The absolute excess risks for cancer at 5, 10, and 20 years after MC diagnosis were + 1.0% (95% confidence interval [C1]0.4%-1.6%), +1.5% [0.4%-2.6%], and + 3.7% [-2.3-9.6%], respectively, equivalent to one extra cancer event in every 55 individuals with MC followed for 10 years. MC was associated with an increased risk of lymphoma (aHR 1.43 [1.06-1.92]) and lung cancer (aHR 1.32 [1.04-1.68]) but with decreased risks of colorectal (aHR 0.52 [0.40-0.66]) and gastrointestinal cancers (aHR 0.72 [0.60-0.85]). We found no association with breast or bladder cancer. Using siblings as reference group to minimise the impact of shared genetic and early environmental factors, patients with MC were still at an increased risk of cancer (HR 1.20 [1.06-1.36]).Conclusions: This nationwide cohort study demonstrated an 8% increased risk of cancer in MC patients. The risk was highest during the first year of follow-up.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Gastroenterologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Gastroenterology and Hepatology hsv//eng
Microscopic colitis
cancer
epidemiology

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Khalili, HamedMassachusetts General Hospital, Crohn’s and Colitis Center and Harvard Medical School, Boston MA, USA; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (author)
Roelstraete, BjornKarolinska Institutet (author)
Ludvigsson, Jonas F.,1969-Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA(Swepub:oru)jsln (author)
Karolinska InstitutetMassachusetts General Hospital, Crohn’s and Colitis Center and Harvard Medical School, Boston MA, USA; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

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In:Journal of Crohn's & Colitis: Oxford University Press15:2, s. 212-2211873-99461876-4479

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