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Prevalence, trends,...
Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer : findings from a national sample
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- Han, Hedong (author)
- Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China; Department of Health Statistics, Second Military Medical University, Shanghai, China
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- Chen, Longpei (author)
- Second Mil Med Univ, Shanghai Changhai Hosp, Dept Med Oncol, Shanghai, Peoples R China.
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- Lin, Zhen (author)
- Department of Medical Oncology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, China
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- Wei, Xin (author)
- Department of Cardiology, Virginia Commonwealth University, Richmond VA, USA; Department of Medicine, Mount Sinai St. Luke’s and West Medical Center, New York NY, USA
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- Guo, Wei (author)
- Department of Health Statistics, Second Military Medical University, Shanghai, China
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- Yu, Yamei (author)
- Department of Cardiology, Shanghai Changning District Central Hospital, Shanghai, China
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- Wu, Cheng (author)
- Department of Health Statistics, Second Military Medical University, Shanghai, China
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- Cao, Yang, Associate Professor, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- He, Jia (author)
- Department of Health Statistics, Second Military Medical University, Shanghai, China; Department of Health Statistics, Tongji University School of Medicine, Shanghai, China
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Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China; Department of Health Statistics, Second Military Medical University, Shanghai, China Second Mil Med Univ, Shanghai Changhai Hosp, Dept Med Oncol, Shanghai, Peoples R China (creator_code:org_t)
- 2021-07-07
- 2021
- English.
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In: Cancer Medicine. - : John Wiley & Sons. - 2045-7634. ; 10:16, s. 5661-5670
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Abstract
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- Background: Epidemiological evidence regarding the link between cancer and atrial fibrillation (AF) are limited and outcomes of metastatic cancer comorbid with AF need to be elucidated.Objective: This study aims to evaluate the prevalence, temporal trends, and outcomes of AF in hospitalized metastatic cancer patients.Methods: The National Inpatient Sample (NIS) database was used to identify adult patients with metastatic tumors from 2003 to 2014. We analyzed the trends in AF prevalence, in-hospital mortality, total cost, length of stay (LOS), and comorbidities pertaining to metastatic cancer. Multivariable-adjusted models were used to evaluate the association of AF with clinical factors, in-hospital mortality, total cost, and LOS.Results: Among 2,478,598 patients with metastatic cancer, 8.74% (216,737) were diagnosed with AF. The proportion of comorbid AF increased from 8.28% in 2003 to 10.06% in 2014 (p < 0.0001). Older age, white race, male, Medicare, higher income, larger hospital bed size, and urban teaching hospital were associated with higher AF occurrence. Among primary tumor sites, lung cancer experienced the highest odds of AF compared to other cancers. Patients with metastasis to lymph node and respiratory organ had higher odds of AF. In metastatic cancer, AF was associated with higher in-hospital mortality (odds ratio: 1.48; 95% confidence interval: 1.43-1.54), 18% longer LOS, and 19% higher cost.Conclusions: AF prevalence in metastatic cancer continues to increase from 2003 to 2014. AF is linked to poorer prognosis and higher healthcare resource utilization. As the population ages, optimal preventive and treatment management strategies are needed for metastatic cancer comorbid with AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- atrial fibrillation
- cancer
- outcomes
- prevalence
- trends
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Han, Hedong
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Chen, Longpei
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Lin, Zhen
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Wei, Xin
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Guo, Wei
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Yu, Yamei
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Wu, Cheng
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Cao, Yang, Assoc ...
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He, Jia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Medicine
- By the university
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Örebro University