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  • Hegvik, Tor-ArneDepartment of Biomedicine, University of Bergen, Bergen, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (author)

Familial co-aggregation of attention-deficit/hyperactivity disorder and autoimmune diseases : a cohort study based on Swedish population-wide registers

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-08-11
  • Oxford University Press,2022
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:oru-93627
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93627URI
  • https://doi.org/10.1093/ije/dyab151DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148778204URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

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  • Funding agency:Stiftelsen Kristian Gerhard JebsenUniversity of BergenWestern Norway Regional Health AuthoritiesSwedish Initiative for Research onMicrodata in the Social And Medical Sciences (SIMSAM) framework 340-2013-5867Strategic Research Programme in Neuroscience (StratNeuro) of Karolinska Institutet
  • BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) has been associated with several autoimmune diseases (AD), both within individuals and across relatives, implying common underlying genetic or environmental factors in line with studies indicating that immunological mechanisms are key to brain development. To further elucidate the relationship between ADHD and autoimmunity we performed a population-wide familial co-aggregation study.METHODS: We linked Swedish national registries, defined a birth cohort with their biological relatives and identified individuals diagnosed with ADHD and/or 13 ADs. The cohort included 5 178 225 individuals born between 1960 and 2010, of whom 118 927 (2.30%) had been diagnosed with ADHD. We then investigated the associations between ADHD and ADs within individuals and across relatives, with logistic regression and structural equation modelling.RESULTS: Within individuals, ADHD was associated with a diagnosis of any of the 13 investigated ADs (adjusted odds ratio (OR) =1.34, 95% confidence interval (CI) = 1.30-1.38) as well as several specific ADs. Familial co-aggregation was observed. For example, ADHD was associated with any of the 13 ADs in mothers (OR = 1.29, 95% CI = 1.26-1.32), fathers (OR = 1.14, 95% CI = 1.11-1.18), full siblings (OR = 1.19, 95% CI = 1.15-1.22), aunts (OR = 1.12, 95% CI = 1.10-1.15), uncles (OR = 1.07, 95% CI = 1.05-1.10) and cousins (OR = 1.04, 95% CI = 1.03-1.06). Still, the absolute risks of AD among those with ADHD were low. The genetic correlation between ADHD and a diagnosis of any of the investigated ADs was 0.13 (95% CI = 0.09-0.17) and the environmental correlation was 0.02 (95% CI = -0.03-0.06).CONCLUSIONS: We found that ADHD and ADs co-aggregate among biological relatives, indicating that the relationship between ADHD and autoimmune diseases may in part be explained by shared genetic risk factors. The patterns of familial co-aggregation of ADHD and ADs do not readily support a role of maternal immune activation in the aetiology of ADHD. The findings have implications for aetiological models of ADHD. However, screening for autoimmunity among individuals with ADHD is not warranted.

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  • Chen, QiKarolinska Institutet (author)
  • Kuja-Halkola, RalfKarolinska Institutet (author)
  • Klungsøyr, KariDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway (author)
  • Butwicka, AgnieszkaKarolinska Institutet (author)
  • Lichtenstein, PaulKarolinska Institutet (author)
  • Almqvist, CatarinaKarolinska Institutet (author)
  • Faraone, Stephen V.Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA (author)
  • Haavik, JanDepartment of Biomedicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway (author)
  • Larsson, Henrik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (author)
  • Karolinska InstitutetDepartment of Biomedicine, University of Bergen, Bergen, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (creator_code:org_t)

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  • In:International Journal of Epidemiology: Oxford University Press51:3, s. 898-9090300-57711464-3685

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